acetaminophen/oxycodone vs phenytoin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of acetaminophen/oxycodone and phenytoin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Inducers of CYP3A4 The concomitant use of PERCOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY ] , resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to PERCOCET [see WARNINGS ] .
Percocet
Dilantin
Percocet is a strong pain medicine. It contains acetaminophen and oxycodone, an opioid.
Phenytoin injection is used to treat certain types of seizures. It can also prevent seizures during or after neurosurgery.
Percocet is used to manage severe pain. It is for pain that requires an opioid medicine. You should only use Percocet if other pain treatments don't work well enough.
This medicine treats generalized tonic-clonic status epilepticus, a type of prolonged seizure. It also helps prevent and treat seizures that may happen during or after brain surgery. Sometimes, it can be used for a short time instead of the oral form of phenytoin when you cannot take the medicine by mouth.
Oxycodone works in the brain to block pain signals. Acetaminophen also helps to reduce pain and fever. Together, they provide stronger pain relief.
Phenytoin works by slowing down the signals in the brain that cause seizures. It stabilizes nerve cell membranes, reducing excessive electrical activity. This helps to prevent seizures from starting or spreading.
- • Lightheadedness
- • Dizziness
- • Drowsiness
- • Nausea
- • Vomiting
No common side effects listed.
- Tiredness 34,486
- Feeling sick to your stomach 29,571
- Head pain 28,378
- Aches 28,322
- Loose stools 23,628
- Drug Interaction 1,547
- Seizure 1,382
- Toxicity To Various Agents 1,353
- Convulsion 1,262
- Status Epilepticus 791
Percocet has a boxed warning. It can cause addiction, abuse, and misuse, leading to overdose and death. It can also cause life-threatening breathing problems, especially when starting or increasing the dose. Accidental ingestion, even one dose, can cause a fatal overdose, especially in children. Taking Percocet with benzodiazepines or other CNS depressants, including alcohol, can cause severe sedation, breathing problems, coma, and death. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn. Acetaminophen can cause liver damage if you take too much.
This medicine can cause serious heart problems if given too quickly. The injection rate should not be faster than 50 mg per minute for adults, and 1 to 3 mg/kg/min (or 50 mg per minute, whichever is slower) for children. Your heart will be monitored closely during and after the injection.
Taking Percocet for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Make sure a newborn specialist is available when you deliver your baby.
Taking phenytoin during pregnancy may increase the risk of birth defects. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of this medicine.
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How to Read This acetaminophen/oxycodone vs phenytoin Comparison
acetaminophen/oxycodone is classified in the Opioid Analgesic Combination drug class, while phenytoin sits within the Anticonvulsant (Hydantoin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acetaminophen/oxycodone has 144,385 submissions while phenytoin has 6,335. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to phenytoin speeds up how your body breaks down oxycodone, which can lower the amount of medicine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for acetaminophen/oxycodone or phenytoin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.