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What the FDA labels say about taking them together

Albendazole and phenytoin

Phenytoin's FDA label of October 15, 2024 names albendazole in its drug interactions section; the albendazole label PlainMeds reads does not name phenytoin. The phenytoin label: “Interacting Agent: Other; Examples: Albendazole, chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine”

Check it at the source: the albendazole FDA label on DailyMed (effective September 30, 2019, Amneal Pharmaceuticals of New York LLC); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).

What does the albendazole label say about phenytoin?

Albendazole's label (effective September 30, 2019) does not name phenytoin in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Albendazole), NDA020666 (Impax Labs Inc), as published by Amneal Pharmaceuticals of New York LLC, effective September 30, 2019 (SPL set 06b5eefc-0b95-4862-b9b6-770063f2adf0), via openFDA; the full label on DailyMed

What does the phenytoin label say about albendazole?

Phenytoin label, drug interactions

Interacting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine

Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

8Albendazole generic labelers
29Phenytoin generic labelers
AlbendazolePhenytoin
Labeled forn/aSeizures and epilepsy
Boxed warningNoNo
Pharmacy cost (NADAC)$4.15 per tablet 200 mg tablet$0.145 per capsule 100 mg capsule
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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