Acamprosate and Diazepam Interaction
Drug interaction information between Acamprosate and Diazepam.
Acamprosate and Diazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acamprosate and Diazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diazepam does not change the way your body absorbs or uses acamprosate. These drugs do not have a known interaction that affects their levels in the blood.
FDA Label Information
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology (12.3) ].
Acamprosate Also Interacts With
- Naltrexone minor
- Disulfiram minor
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Acamprosate + Diazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diazepam has 26 labeled pairs on file vs Acamprosate's 3. In the minor band specifically: Acamprosate has 3 (also Naltrexone, Disulfiram); Diazepam has 22 (also Omeprazole, Ketoconazole, Fluvoxamine, Cimetidine).
What mechanism field is on file for Acamprosate and Diazepam?
Diazepam does not change the way your body absorbs or uses acamprosate. These drugs do not have a known interaction that affects their levels in the blood.
Diazepam's labeled portfolio outnumbers Acamprosate
SPL source-record counts only. This page's band is minor · classes on file: Acamprosate (GABA Analog (Alcohol Dependence)); Diazepam (Benzodiazepine).
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Acamprosate
- Naltrexone
- Disulfiram
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Ketoconazole
- Fluvoxamine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.