Methylprednisolone · larger labeled portfolio than Amphotericin B
SPL labels Methylprednisolone + Amphotericin B as minor; Methylprednisolone 22 / Amphotericin B 9 in that band.
Mechanism on file: Both drugs can cause your body to lose too much potassium, which is a mineral your heart needs to work properly. Low potassium levels can lead to heart problems like an enlarged heart or heart failure.
FDA SPL severity: Minor
Methylprednisolone + Amphotericin B · SPL mechanism field
Both drugs can cause your body to lose too much potassium, which is a mineral your heart needs to work properly. Low potassium levels can lead to heart problems like an enlarged heart or heart failure.
Minor band excerpt · Methylprednisolone with Amphotericin B
Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure.
Methylprednisolone · 29 SPL pairs (broader portfolio than Amphotericin B)
- Acetaminophen minor
- Carbamazepine minor
- Chloroquine minor
- Cholestyramine minor
Amphotericin B · 9 minor + 12 total pairs
- Anidulafungin minor
- Dexamethasone minor
- Dronabinol minor
- Fluconazole minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.