What the FDA labels say about taking them together
Cholestyramine and methylprednisolone
Methylprednisolone's FDA label (Solu-Medrol) of December 2, 2025 names cholestyramine in its drug interactions section; the cholestyramine label PlainMeds reads does not name methylprednisolone. The methylprednisolone label: “Cholestyramine: Cholestyramine may increase the clearance of corticosteroids.”
Check it at the source: the cholestyramine FDA label on DailyMed (effective August 20, 2026, AiPing Pharmaceutical, Inc.); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the cholestyramine label say about methylprednisolone?
Cholestyramine's label (effective August 20, 2026) does not name methylprednisolone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cholestyramine), AiPing Pharmaceutical, Inc., effective August 20, 2026 (SPL set 214ea05f-de81-4026-9df9-4ce3820668ee), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about cholestyramine?
Solu-Medrol label (Pharmacia & Upjohn Company LLC, December 2, 2025), drug interactionsCholestyramine: Cholestyramine may increase the clearance of corticosteroids.
Source: FDA drug label (Solu-Medrol, NDA011856), Pharmacia & Upjohn Company LLC, effective December 2, 2025 (SPL set cd99be87-c8d9-48d6-a8e5-e081052e3f19), via openFDA
Source: FDA drug label (Depo-Medrol, NDA011757), Pharmacia & Upjohn Company LLC, effective January 21, 2026 (SPL set 823b0010-2b57-4e76-b5ac-4a8c2963438f), via openFDA
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cholestyramine | Methylprednisolone | |
|---|---|---|
| Labeled for | High cholesterol | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.834 per packet Cholestyramine packet | $0.121 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once