Loperamide and Itraconazole Interaction
Drug interaction information between Loperamide and Itraconazole.
Loperamide and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Loperamide and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole can stop your body from breaking down loperamide properly, leading to higher levels of the medicine in your blood.
FDA Label Information
Aprepitant Loperamide a Monitor for adverse reactions.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Loperamide + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Loperamide's 2. In the minor band specifically: Loperamide has 1; Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Loperamide and Itraconazole?
Itraconazole can stop your body from breaking down loperamide properly, leading to higher levels of the medicine in your blood.
Itraconazole carries more major-labeled pairs than Loperamide
SPL source-record counts only. This page's band is minor · classes on file: Loperamide (Antidiarrheal (Opioid Receptor Agonist)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Loperamide's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 1 minor · 2 total
Loperamide has no other minor-band peer in this dataset besides Itraconazole.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.