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itraconazole vs loperamide

Side-by-side comparison of itraconazole and loperamide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

Aprepitant Loperamide a Monitor for adverse reactions.

Recommendation: You should be monitored for any unusual reactions or side effects.

Drug Class
itraconazole Azole Antifungal
loperamide Antidiarrheal (Opioid Receptor Agonist)
Type
itraconazole Prescription
loperamide Over-the-Counter
Summary
itraconazole

Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.

loperamide

Loperamide (Imodium) helps control diarrhea symptoms. It is also used for Traveler's Diarrhea.

What It Treats
itraconazole

Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.

loperamide

This medicine treats diarrhea. It can also help with Traveler's Diarrhea. It works to reduce bowel movements and relieve symptoms like stomach cramps.

How It Works
itraconazole

Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.

loperamide

Loperamide works by slowing down your intestines. This allows more water to be absorbed from your stool. This makes your stools less watery and reduces how often you need to go to the bathroom.

Common Side Effects
itraconazole
  • Nausea
  • Rash
  • Headache
loperamide
  • Headache
  • Dizziness
  • Constipation
  • Nausea
FAERS Reports
itraconazole
  • Interaction with another medicine 1,118
  • Fever 570
  • Difficulty breathing 472
  • Lung infection 462
  • Feeling sick to your stomach 446
loperamide
  • Diarrhea 8,466
  • Feeling sick to your stomach 4,091
  • Feeling tired 3,692
  • Throwing up 2,673
  • Having trouble pooping 2,352
Serious Warnings
itraconazole

Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.

loperamide

Taking too much loperamide can cause serious heart problems. Always follow the recommended dose.

Pregnancy
itraconazole

You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.

loperamide

Talk to your doctor before taking this medicine if you are pregnant or breastfeeding. It is not known if loperamide can harm your unborn baby or pass into breast milk.

Also Compare, Nearby Drugs

How to Read This itraconazole vs loperamide Comparison

itraconazole is classified in the Azole Antifungal drug class, while loperamide sits within the Antidiarrheal (Opioid Receptor Agonist) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,068 submissions while loperamide has 21,274. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole can stop your body from breaking down loperamide properly, leading to higher levels of the medicine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between itraconazole and loperamide - always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.