Leflunomide and Rosuvastatin Interaction
Drug interaction information between Leflunomide and Rosuvastatin.
Leflunomide and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Leflunomide and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Leflunomide changes how your body processes rosuvastatin, which can cause the amount of the cholesterol medicine in your blood to increase.
FDA Label Information
For a patient taking leflunomide, the dose of rosuvastatin should not exceed 10 mg once daily. ( 7 ) Rosuvastatin: The dose of rosuvastatin should not exceed 10 mg once daily in patients taking leflunomide.
Leflunomide Also Interacts With
- Atorvastatin minor
- Simvastatin minor
- Furosemide minor
- Duloxetine minor
- Pravastatin minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Leflunomide + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Leflunomide's 20. In the minor band specifically: Leflunomide has 20 (also Atorvastatin, Simvastatin, Furosemide, Duloxetine); Rosuvastatin has 10 (also Fenofibrate, Warfarin, Brexpiprazole, Darunavir).
What mechanism field is on file for Leflunomide and Rosuvastatin?
Leflunomide changes how your body processes rosuvastatin, which can cause the amount of the cholesterol medicine in your blood to increase.
Rosuvastatin carries more major-labeled pairs than Leflunomide
SPL source-record counts only. This page's band is minor · classes on file: Leflunomide (Disease-Modifying Antirheumatic Drug (DMARD)); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Leflunomide's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 20 minor · 20 total
- Other minor peers for Leflunomide
- Atorvastatin
- Simvastatin
- Furosemide
- Duloxetine
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Brexpiprazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.