Leflunomide and Duloxetine Interaction
Drug interaction information between Leflunomide and Duloxetine.
Leflunomide and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Leflunomide and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Leflunomide speeds up how fast your body breaks down duloxetine, which can lower the amount of medicine in your system and make it less effective.
FDA Label Information
In patients taking leflunomide, exposure of drugs metabolized by CYP1A2 (e.g., alosetron, duloxetine, theophylline, tizanidine) may be reduced.
Leflunomide Also Interacts With
- Atorvastatin minor
- Rosuvastatin minor
- Simvastatin minor
- Furosemide minor
- Pravastatin minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Leflunomide + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Leflunomide has 20 labeled pairs on file vs Duloxetine's 18. In the minor band specifically: Leflunomide has 20 (also Atorvastatin, Rosuvastatin, Simvastatin, Furosemide); Duloxetine has 17 (also Fluoxetine, Famotidine, Buspirone, Paroxetine).
What mechanism field is on file for Leflunomide and Duloxetine?
Leflunomide speeds up how fast your body breaks down duloxetine, which can lower the amount of medicine in your system and make it less effective.
Leflunomide's labeled portfolio outnumbers Duloxetine
SPL source-record counts only. This page's band is minor · classes on file: Leflunomide (Disease-Modifying Antirheumatic Drug (DMARD)); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 20 minor · 20 total
- Other minor peers for Leflunomide
- Atorvastatin
- Rosuvastatin
- Simvastatin
- Furosemide
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.