Enoxaparin and Rivaroxaban Interaction
Drug interaction information between Enoxaparin and Rivaroxaban.
Enoxaparin and Rivaroxaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Enoxaparin and Rivaroxaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are blood thinners that work in different ways to prevent clots. Taking them together makes your blood much thinner and increases your chance of dangerous bleeding.
FDA Label Information
7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].
Enoxaparin Also Interacts With
- Ketorolac minor
- Dipyridamole minor
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Ketoconazole moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Enoxaparin + Rivaroxaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rivaroxaban has 14 labeled pairs on file vs Enoxaparin's 3. In the moderate band specifically: Enoxaparin has 1; Rivaroxaban has 13 (also Clopidogrel, Aspirin, Warfarin, Ketoconazole).
What mechanism field is on file for Enoxaparin and Rivaroxaban?
Both drugs are blood thinners that work in different ways to prevent clots. Taking them together makes your blood much thinner and increases your chance of dangerous bleeding.
Rivaroxaban's labeled portfolio outnumbers Enoxaparin
SPL source-record counts only. This page's band is moderate · classes on file: Enoxaparin (Low-Molecular-Weight Heparin); Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
0 major · 1 moderate · 2 minor · 3 total
Enoxaparin has no other moderate-band peer in this dataset besides Rivaroxaban.
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Clopidogrel
- Aspirin
- Warfarin
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.