Itraconazole · more major-labeled pairs than Apixaban
SPL labels Itraconazole + Apixaban as minor; Itraconazole 77 / Apixaban 3 in that band.
Mechanism on file: Itraconazole blocks the enzymes and proteins that remove apixaban from your body, which can cause the drug to build up.
FDA SPL severity: Minor
Itraconazole + Apixaban · SPL mechanism field
Itraconazole blocks the enzymes and proteins that remove apixaban from your body, which can cause the drug to build up.
Minor band excerpt · Itraconazole with Apixaban
( 7.2 , 12.3 ) 7.1 Combined P-gp Strong CYP3A4 Inhibitors For patients receiving apixaban 5 mg or 10 mg twice daily, the dose of apixaban should be decreased by 50% when coadministered with drugs that are combined P-gp and strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) [see Dosage and Administration (2.5) and Clinical Pharmacology ( 12.3) ].
Itraconazole · 19 major-labeled pairs (vs Apixaban's 0)
- Aprepitant minor
- Aripiprazole minor
- Bazedoxifene/Conjugated Estrogens minor
- Budesonide minor
Apixaban · 3 minor + 12 total pairs
- Clarithromycin minor
- Ketoconazole minor
- Aspirin moderate
- Carbamazepine moderate
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.