What the FDA labels say about taking them together
Budesonide and itraconazole
Budesonide's FDA label of October 11, 2019 names itraconazole in its drug interactions section, and itraconazole's label names budesonide too. The budesonide label: “Inhibitors of CYP3A4 can increase systemic budesonide concentrations.”
Check it at the source: the budesonide FDA label on DailyMed (effective October 11, 2019, AstraZeneca Pharmaceuticals LP); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the budesonide label say about itraconazole?
Budesonide label, drug interactionsCaution should be exercised when considering the coadministration of PULMICORT RESPULES with long-term ketoconazole and other known strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, telithromycin) [see Warnings and Precautions (5.12), Clinical Pharmacology (12.3) ].
Budesonide label, warnings and precautionsInteractions with Strong Cytochrome P450 3A4 Inhibitors Caution should be exercised when considering the coadministration of PULMICORT RESPULES with ketoconazole, and other known strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, telithromycin) because adverse effects related to increased systemic exposure to budesonide may occur [see Drug Interactions (7.1), Clinical Pharmacology (12.3) ].
Eohilia label (TAKEDA PHARMACEUTICALS AMERICA, INC., February 3, 2025), drug interactionsConcomitant use of budesonide with CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, cyclosporine, grapefruit juice) can increase systemic budesonide concentrations [see Clinical Pharmacology (12.3) ].
Tarpeyo label (Calliditas Therapeutics AB, January 21, 2026), drug interactionsAvoid use with potent CYP3A4 inhibitors; e.g. ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, and cyclosporine [see Clinical Pharmacology ( 12.3 )].
Budesonide label (Padagis US LLC, June 5, 2024), drug interactionsInhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, and cyclosporine) can increase systemic budesonide concentrations [see Clinical Pharmacology (12.3)].
Source: FDA drug label (Eohilia, NDA213976), TAKEDA PHARMACEUTICALS AMERICA, INC., effective February 3, 2025 (SPL set 56f2023a-69b2-4470-b4ad-af7ec1be527a), via openFDA
Source: FDA drug label (Tarpeyo, NDA215935), Calliditas Therapeutics AB, effective January 21, 2026 (SPL set 938cada4-d6bf-4252-836f-dd40f9eadb4d), via openFDA
Source: FDA drug label (PULMICORT RESPULES), AstraZeneca Pharmaceuticals LP, effective October 11, 2019 (SPL set 33cd9834-76df-4f26-3fa2-aab6b9eee8f2), via openFDA; the full label on DailyMed
What does the itraconazole label say about budesonide?
Itraconazole label, drug interactionsExamples of Concomitant Drugs Within Class: Budesonide (inhalation) Budesonide (non-inhalation) Ciclesonide (inhalation) Cyclosporine (IV) Cyclosporine (non-IV) Dexamethasone; Prevention or Management: Fluticasone (inhalation) Fluticasone (nasal) Methylprednisolone Tacrolimus (IV) Tacrolimus (oral); Monitor for adverse reactions. Concomitant drug dose reduction may be necessary.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Budesonide | Itraconazole | |
|---|---|---|
| Labeled for | Asthma, Allergies, Crohn's disease and ulcerative colitis | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.498 per capsule 3 mg capsule | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once