What the FDA labels say about taking them together
Aprepitant and itraconazole
Aprepitant's FDA label of July 5, 2024 names itraconazole in its drug interactions section, and itraconazole's label names aprepitant too. The itraconazole label: “Gastrointestinal Drugs Naloxegol Contraindicated during and 2 weeks after TOLSURA treatment. Aprepitant Loperamide Monitor for adverse reactions.”
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the aprepitant label say about itraconazole?
Aprepitant label, drug interactionsExamples; Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir
Source: FDA drug label (Aponvie, NDA216457), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set d1b111eb-659a-496b-a86a-8f0fa370f147), via openFDA
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the itraconazole label say about aprepitant?
Itraconazole label, drug interactionsGastrointestinal Drugs Cisapride Naloxegol Contraindicated during and 2 weeks after SPORANOX ® treatment. Aprepitant Loperamide Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Itraconazole | |
|---|---|---|
| Labeled for | Nausea and vomiting | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once