Octreotide and Insulin Human/Insulin Isophane Interaction
Drug interaction information between Octreotide and Insulin Human/Insulin Isophane.
Octreotide and Insulin Human/Insulin Isophane have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Octreotide and Insulin Human/Insulin Isophane. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Octreotide can lower blood sugar levels, which adds to the effect of insulin and makes low blood sugar more likely.
What To Do
Your doctor may need to adjust your insulin dose and you should check your blood sugar more often.
FDA Label Information
7 DRUG INTERACTIONS Table 1: Clinically Significant Drug Interactions with HUMULIN 70/30 Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN 70/30 is co-administered with these drugs.
Octreotide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
Insulin Human/Insulin Isophane Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Frequently Asked Questions
Can I take Octreotide and Insulin Human/Insulin Isophane together?
This is a moderate interaction. Your doctor may need to adjust your insulin dose and you should check your blood sugar more often.
How serious is the interaction between Octreotide and Insulin Human/Insulin Isophane?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Octreotide and Insulin Human/Insulin Isophane interact?
Octreotide can lower blood sugar levels, which adds to the effect of insulin and makes low blood sugar more likely.
Understanding the Octreotide and Insulin Human/Insulin Isophane Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Octreotide belongs to the Somatostatin Analog class and Insulin Human/Insulin Isophane belongs to the Intermediate-Acting Insulin Combination class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Octreotide can lower blood sugar levels, which adds to the effect of insulin and makes low blood sugar more likely. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Octreotide has 14 total documented interactions on file in this dataset, and Insulin Human/Insulin Isophane has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your insulin dose and you should check your blood sugar more often. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Octreotide or Insulin Human/Insulin Isophane based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.