Fosinopril and Propranolol Interaction
Drug interaction information between Fosinopril and Propranolol.
Fosinopril and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fosinopril and Propranolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not interfere with each other's levels in the body when they are taken together.
What To Do
No dosage adjustments are generally required when using this combination of medications.
FDA Label Information
In separate single or multiple dose pharmacokinetic interaction studies with chlorthalidone, nifedipine, propranolol, hydrochlorothiazide, cimetidine, metoclopramide, propantheline, digoxin, and warfarin, the bioavailability of fosinoprilat was not altered by coadministration of fosinopril with any one of these drugs.
Fosinopril Also Interacts With
- Aliskiren major
- Lithium moderate
- Hydrochlorothiazide minor
- Aspirin minor
- Warfarin minor
Frequently Asked Questions
Can I take Fosinopril and Propranolol together?
This is a minor interaction. No dosage adjustments are generally required when using this combination of medications.
How serious is the interaction between Fosinopril and Propranolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Fosinopril and Propranolol interact?
These two drugs do not interfere with each other's levels in the body when they are taken together.
Understanding the Fosinopril and Propranolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Fosinopril belongs to the ACE Inhibitor class and Propranolol belongs to the Non-Selective Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not interfere with each other's levels in the body when they are taken together. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Fosinopril has 12 total documented interactions on file in this dataset, and Propranolol has 44. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dosage adjustments are generally required when using this combination of medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Fosinopril or Propranolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.