Fluticasone/Vilanterol and Ketoconazole Interaction
Drug interaction information between Fluticasone/Vilanterol and Ketoconazole.
Fluticasone/Vilanterol and Ketoconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluticasone/Vilanterol and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole interferes with how your body processes the inhaler, which can result in higher-than-normal levels of the medicine in your body.
FDA Label Information
7 DRUG INTERACTIONS • Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol. Caution should be exercised when considering the coadministration of BREO ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.9 ), Clinical Pharmacology ( 12.3 )] .
Fluticasone/Vilanterol Also Interacts With
- Fluticasone minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Fluticasone/Vilanterol + Ketoconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Fluticasone/Vilanterol's 2. In the moderate band specifically: Fluticasone/Vilanterol has 1; Ketoconazole has 22 (also Alprazolam, Aprepitant, Budesonide/Formoterol, Dexamethasone).
What mechanism field is on file for Fluticasone/Vilanterol and Ketoconazole?
Ketoconazole interferes with how your body processes the inhaler, which can result in higher-than-normal levels of the medicine in your body.
Ketoconazole carries more major-labeled pairs than Fluticasone/Vilanterol
SPL source-record counts only. This page's band is moderate · classes on file: Fluticasone/Vilanterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Fluticasone/Vilanterol's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 1 minor · 2 total
Fluticasone/Vilanterol has no other moderate-band peer in this dataset besides Ketoconazole.
6 major · 22 moderate · 85 minor · 113 total
- Other moderate peers for Ketoconazole
- Alprazolam
- Aprepitant
- Budesonide/Formoterol
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.