Fluconazole · more major-labeled pairs than Carvedilol
SPL labels Fluconazole + Carvedilol as minor; Fluconazole 57 / Carvedilol 12 in that band.
Mechanism on file: Fluconazole prevents the body from breaking down carvedilol properly. This leads to higher levels of the drug in your system, which can slow your heart rate too much.
FDA SPL severity: Minor
Fluconazole + Carvedilol · SPL mechanism field
Fluconazole prevents the body from breaking down carvedilol properly. This leads to higher levels of the drug in your system, which can slow your heart rate too much.
Minor band excerpt · Fluconazole with Carvedilol
The concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with carvedilol may enhance the β-blocking activity, resulting in further slowing of the heart rate or cardiac conduction.
Fluconazole · 3 major-labeled pairs (vs Carvedilol's 0)
- Amitriptyline minor
- Amlodipine minor
- Amphotericin B minor
- Azithromycin minor
Carvedilol · 12 minor + 13 total pairs
- Amiodarone minor
- Cimetidine minor
- Cyclosporine minor
- Darunavir minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.