What the FDA labels say about taking them together
Carvedilol and cimetidine
Carvedilol's FDA label of July 31, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name carvedilol. The carvedilol label: “Cimetidine increased AUC by about 30% but caused no change in C max.”
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the carvedilol label say about cimetidine?
Carvedilol label, drug interactionsCimetidine increased AUC by about 30% but caused no change in C max [see Clinical Pharmacology (12.5) ].
Coreg Cr label (Waylis Therapeutics LLC, April 25, 2025), drug interactionsCimetidine increased area under the curve (AUC) by about 30% but caused no change in C max [see Drug-Drug Interactions (12.5) ].
Source: FDA drug label (Coreg Cr, NDA022012), Waylis Therapeutics LLC, effective April 25, 2025 (SPL set d3625d78-6eb6-41fe-8f6f-664965c104c4), via openFDA
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the cimetidine label say about carvedilol?
Cimetidine's label (effective July 15, 2026) does not name carvedilol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Cimetidine | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | $0.236 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once