Amiodarone · more major-labeled pairs than Carvedilol
SPL labels Carvedilol + Amiodarone as minor; Carvedilol 12 / Amiodarone 29 in that band.
Mechanism on file: Amiodarone blocks the proteins that normally break down carvedilol, which can cause carvedilol to build up and slow your heart rate too much.
FDA SPL severity: Minor
Carvedilol + Amiodarone · SPL mechanism field
Amiodarone blocks the proteins that normally break down carvedilol, which can cause carvedilol to build up and slow your heart rate too much.
Minor band excerpt · Carvedilol with Amiodarone
( 7.4 ) Amiodarone may increase carvedilol levels resulting in further slowing of the heart rate or cardiac conduction. 7.6 Amiodarone Amiodarone and its metabolite desethyl amiodarone, inhibitors of CYP2C9, and P-glycoprotein increased concentrations of the S(-)-enantiomer of carvedilol by at least 2 fold [see Clinical Pharmacology ( 12.5 )] . The concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with carvedilol may enhance the β-blocking activity, resulting in further slowing of the heart rate or cardiac conduction.
Carvedilol · 12 minor + 13 total pairs
- Cimetidine minor
- Cyclosporine minor
- Darunavir minor
- Digoxin minor
Amiodarone · 4 major-labeled pairs (vs Carvedilol's 0)
- Atenolol minor
- Atorvastatin minor
- Cholestyramine minor
- Cimetidine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.