What the FDA labels say about taking them together
Amitriptyline and fluconazole
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names amitriptyline in its drug interactions section; the amitriptyline label PlainMeds reads does not name fluconazole. The fluconazole label: “Amitriptyline, nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline.”
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the amitriptyline label say about fluconazole?
Amitriptyline's label (effective September 8, 2026) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the fluconazole label say about amitriptyline?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsAmitriptyline, nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Fluconazole | |
|---|---|---|
| Labeled for | Depression | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once