erythromycin vs sildenafil
Side-by-side comparison of erythromycin and sildenafil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7 DRUG INTERACTIONS Sildenafil can potentiate the hypotensive effects of nitrates, alpha blockers, and anti-hypertensives ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) With concomitant use of alpha blockers, initiate sildenafil at 25 mg dose ( 2.3 ) CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase sildenafil exposure ( 2.4 , 7.4 , 12.3 ) Ritonavir: Do not exceed a maximum single dose of 25 mg in a 48 hour period ( 2.4 , 5.6 ) Erythromycin or strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, saquinavir): Consider a starting dose of 25 mg ( 2.4 , 7.4...
Recommendation: Your doctor should consider starting you on a lower dose of 25 mg of sildenafil.
E-Mycin, Ery-Tab
Viagra, Revatio
Erythromycin Topical Solution is a medicine that you put on your skin to treat acne. It contains an antibiotic to help clear up your skin.
Sildenafil is a medicine used to treat erectile dysfunction (ED) in men. It helps increase blood flow to the penis to get and keep an erection.
Erythromycin Topical Solution treats acne vulgaris. This medicine helps to reduce acne on your face, neck, shoulders, chest, and back. It works by fighting the bacteria that cause acne.
Sildenafil is used to treat erectile dysfunction (ED), also known as impotence, in men. ED is when you cannot get or keep an erection firm enough for sex. Sildenafil helps by increasing blood flow to the penis when you are sexually stimulated.
Erythromycin is a macrolide antibiotic. It works by stopping the growth of bacteria. This helps to reduce inflammation and clear up acne.
Sildenafil belongs to a class of drugs called PDE5 inhibitors. It works by relaxing the muscles and increasing blood flow to the penis during sexual stimulation. This helps you get and keep an erection.
- • Peeling
- • Dryness
- • Itching
- • Redness
- • Oily skin
- • Headache
- • Flushing (redness of the skin)
- • Upset stomach
- • Abnormal vision (blurred vision, changes in color vision)
- • Nasal congestion (stuffy nose)
- Drug Hypersensitivity 4,088
- Nausea 1,271
- Vomiting 1,121
- Diarrhoea 1,069
- Dyspnoea 1,023
- Shortness of breath 7,729
- Headache 5,655
- Diarrhea 4,447
- Nausea 3,984
- Death 3,872
You should not use this medicine if you are allergic to any of its ingredients.
You should not take sildenafil if you are taking nitrates for chest pain, as this can cause a dangerous drop in blood pressure. If you have an erection that lasts longer than 4 hours, get medical help right away. Stop taking sildenafil and seek medical attention if you have a sudden loss of vision or hearing.
It is not known if erythromycin topical solution can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding.
Sildenafil is not for use in women. It is not known if sildenafil can harm an unborn baby or pass into breast milk.
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How to Read This erythromycin vs sildenafil Comparison
erythromycin is classified in the Macrolide Antibiotic drug class, while sildenafil sits within the PDE5 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, erythromycin has 8,572 submissions while sildenafil has 25,687. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to erythromycin prevents your body from processing sildenafil normally, which increases the amount of medicine in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between erythromycin and sildenafil - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.