Dutasteride/Tamsulosin and Paroxetine Interaction
Drug interaction information between Dutasteride/Tamsulosin and Paroxetine.
Dutasteride/Tamsulosin and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dutasteride/Tamsulosin and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine stops an enzyme from breaking down tamsulosin, which causes the drug levels in your body to rise.
FDA Label Information
Concomitant treatment with paroxetine (a strong inhibitor of CYP2D6) resulted in increases in the C max and area under the concentration-time curve (AUC) of tamsulosin by factors of 1.3 and 1.6, respectively.
Dutasteride/Tamsulosin Also Interacts With
- Furosemide major
- Tamsulosin moderate
- Warfarin moderate
- Atenolol minor
- Diltiazem minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Dutasteride/Tamsulosin + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Dutasteride/Tamsulosin's 15. In the minor band specifically: Dutasteride/Tamsulosin has 12 (also Atenolol, Diltiazem, Nifedipine, Ketoconazole); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Dutasteride/Tamsulosin and Paroxetine?
Paroxetine stops an enzyme from breaking down tamsulosin, which causes the drug levels in your body to rise.
Paroxetine carries more major-labeled pairs than Dutasteride/Tamsulosin
SPL source-record counts only. This page's band is minor · classes on file: Dutasteride/Tamsulosin (5-ARI / Alpha-Blocker Combination); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Dutasteride/Tamsulosin's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 12 minor · 15 total
- Other minor peers for Dutasteride/Tamsulosin
- Atenolol
- Diltiazem
- Nifedipine
- Ketoconazole
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.