Prescription medication · 5-ARI / Alpha-Blocker Combination

dutasteride/tamsulosin

Also sold as Jalyn. This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men.

Data updated 2026-05-15

8,615
FDA reports
15
InteractionsSeveral interactions
$21.67
Brand price (NADAC)

What the data shows

dutasteride/tamsulosin (Jalyn) is a prescription 5-ARI / Alpha-Blocker Combination, with 8,615 FDA adverse-event reports on file, with 15 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

dutasteride/tamsulosin (Jalyn) is a prescription 5-ARI / Alpha-Blocker Combination. This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men.

This medicine combines two drugs to treat enlarged prostate in men. It helps improve urine flow and reduce symptoms.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$21.67/unit

Generic Available

No

Pricing data from NADAC (CMS), effective June 2, 2023. Compare all drug costs →

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What it does

This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men.

Common side effects

Problems with ejaculation, Impotence (trouble getting or keeping an erection), Decreased sex drive

Key warnings

This medicine can cause dizziness, lightheadedness, and fainting, especially when you stand up.

The sections below are summarized in plain English from dutasteride/tamsulosin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

This medicine contains two drugs that work in different ways. Dutasteride lowers a hormone called DHT that causes the prostate to grow. Tamsulosin relaxes the muscles in the prostate and bladder, making it easier to urinate.

Side Effects (from patient reports)

Based on 8,615 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for dutasteride/tamsulosin, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

This medicine can cause dizziness, lightheadedness, and fainting, especially when you stand up. Be careful to avoid falls or injuries. Do not take this medicine with other alpha-blockers, as it can lower your blood pressure too much. This medicine can affect your PSA levels, which are used to screen for prostate cancer, so tell your doctor you are taking this medicine. Pregnant women should not handle this medicine, as it can harm a male fetus.

Known Drug Interactions

major furosemide

7.5 Furosemide Tamsulosin Tamsulosin had no effect on the pharmacodynamics (excretion of electrolytes) of furosemide. While furosemide produced an 11% to 12% reduction in tamsulosin hydrochloride C max and AUC, these changes are expected to be clinically insignificant and do not require adjustment of the dose of tamsulosin [see Clinical Pharmacology ( 12.3 ) ] .

Mechanism: Furosemide can slightly decrease the levels of tamsulosin in your body, but it does not change how well the water pill works.

moderate tamsulosin

7 DRUG INTERACTIONS There have been no drug interaction trials using dutasteride and tamsulosin hydrochloride capsules. Because of the potential for drug-drug interactions, use caution when prescribing a dutasteride-containing product, including dutasteride and tamsulosin hydrochloride capsules, to patients taking potent, chronic CYP3A4 enzyme inhibitors (e.g., ritonavir) [see Clinical Pharmacology ( 12.3 ) ] . Tamsulosin Strong and Moderate Inhibitors of CYP3A4 or CYP2D6: Tamsulosin is extensively metabolized, mainly by CYP3A4 or CYP2D6.

Mechanism: Taking both of these means you are taking the same medicine twice, which can cause your blood pressure to drop too low or cause other side effects.

moderate warfarin

7.2 Warfarin Dutasteride Concomitant administration of dutasteride 0.5 mg/day for 3 weeks with warfarin does not alter the steady-state pharmacokinetics of the S- or R-warfarin isomers or alter the effect of warfarin on prothrombin time [see Clinical Pharmacology ( 12.3 ) ] . Tamsulosin A definitive drug-drug interaction trial between tamsulosin hydrochloride and warfarin was not conducted. Caution should be exercised with concomitant administration of warfarin and tamsulosin-containing products, including dutasteride and tamsulosin hydrochloride capsules [see Warnings and Precautions (...

Mechanism: One part of this combination medicine has not been fully tested with blood thinners, so it is unclear how they might affect each other.

minor paroxetine

Concomitant treatment with paroxetine (a strong inhibitor of CYP2D6) resulted in increases in the C max and area under the concentration-time curve (AUC) of tamsulosin by factors of 1.3 and 1.6, respectively.

Mechanism: Paroxetine stops an enzyme from breaking down tamsulosin, which causes the drug levels in your body to rise.

minor atenolol

7.3 Nifedipine, Atenolol, Enalapril Tamsulosin Dosage adjustments are not necessary when tamsulosin is administered concomitantly with nifedipine, atenolol, or enalapril [see Clinical Pharmacology ( 12.3 ) ] .

Mechanism: These medications do not significantly affect how the other drug is handled by the body.

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This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can women take this medicine?
No, this medicine is only for men.
Can this medicine prevent prostate cancer?
No, this medicine is not approved to prevent prostate cancer.
What should I do if I feel dizzy after taking this medicine?
Sit or lie down until the dizziness passes. Be careful when standing up.
Does this medicine interact with other medications?
Yes, it can interact with some medications. Tell your doctor about all the medicines you take.
Can I donate blood while taking this medicine?
No, you should not donate blood until 6 months after your last dose.
What if I am planning to have cataract or glaucoma surgery?
Tell your eye doctor that you are taking or have taken this medicine.
How long does it take for this medicine to work?
It may take several weeks to see the full effects of this medicine.
Can I stop taking this medicine if my symptoms improve?
Do not stop taking this medicine without talking to your doctor first.
What should I do if the capsule contents come into contact with my mouth?
Rinse your mouth with water to avoid irritation.
Can this medicine affect my PSA levels?
Yes, this medicine can lower your PSA levels. Your doctor will still monitor your PSA levels for prostate cancer.
What are the common side effects of dutasteride/tamsulosin?
The registry lists Problems with ejaculation, Impotence (trouble getting or keeping an erection), Decreased sex drive, Dizziness, Breast enlargement or tenderness among the most-reported FAERS reaction terms for dutasteride/tamsulosin. The compiled record contains 8,615 FDA adverse-event reports. These counts are not an individual symptom assessment.
Does dutasteride/tamsulosin interact with other medications?
The registry has 15 documented interaction rows for dutasteride/tamsulosin. Notable source-record pairings include furosemide, tamsulosin, warfarin. These rows are not a complete medication review.
What drug class is dutasteride/tamsulosin?
dutasteride/tamsulosin belongs to the 5-ARI / Alpha-Blocker Combination drug class. It requires a prescription (Rx). This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men.
What pregnancy or breastfeeding source fields are listed for dutasteride/tamsulosin?
The FDA label for dutasteride/tamsulosin contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in 5-ARI / Alpha-Blocker Combination

Other drugs grouped near dutasteride/tamsulosin - same-class peers and common alternatives.

alfuzosin

Uroxatral

Alfuzosin is a medicine that helps men with enlarged prostate glands.

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bethanechol

Urecholine

Bethanechol helps you to urinate if you have trouble emptying your bladder.

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darifenacin

Enablex

Darifenacin (Enablex) is a medicine that helps control an overactive bladder.

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dutasteride

Avodart

Dutasteride and tamsulosin hydrochloride capsules contain two medicines to treat enlarged prostate in men.

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fesoterodine

Toviaz

Fesoterodine is a medicine that helps control an overactive bladder.

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Compare dutasteride/tamsulosin vs alfuzosin side-by-side →

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What the FDA Data Shows for dutasteride/tamsulosin

The FDA label for dutasteride/tamsulosin (sold under brand names such as Jalyn) classifies it as a prescription-only medication in the 5-ARI / Alpha-Blocker Combination class. This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men. Official labeling lists 5 commonly reported side effects, including Problems with ejaculation, Impotence (trouble getting or keeping an erection), Decreased sex drive.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 8,615 voluntary reports. The database also lists 15 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: January 13, 2026

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page