Doxepin and Ramelteon Interaction
Drug interaction information between Doxepin and Ramelteon.
Doxepin and Ramelteon have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Doxepin and Ramelteon. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking doxepin can raise the levels of ramelteon in your body by slowing down its breakdown.
FDA Label Information
( 7.1 ) Doxepin: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with doxepin. Doxepin The AUC 0-inf and C max of ramelteon increased by approximately 66% and 69%, respectively, upon coadministration of doxepin with ramelteon. Patients should be closely monitored when ramelteon is coadministered with doxepin [see Clinical Pharmacology (12.5) ] .
Ramelteon Also Interacts With
- Ketoconazole moderate
- Fluconazole moderate
- Donepezil minor
- Rifampin minor
- Fluvoxamine minor
Frequently Asked Questions
What SPL severity band is on file for Doxepin + Ramelteon?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ramelteon has 7 labeled pairs on file vs Doxepin's 3. In the minor band specifically: Doxepin has 3 (also Cimetidine, Dopamine); Ramelteon has 5 (also Donepezil, Rifampin, Fluvoxamine, Itraconazole).
What mechanism field is on file for Doxepin and Ramelteon?
Taking doxepin can raise the levels of ramelteon in your body by slowing down its breakdown.
Ramelteon's labeled portfolio outnumbers Doxepin
SPL source-record counts only. This page's band is minor · classes on file: Doxepin (Tricyclic Antidepressant (TCA)); Ramelteon (Melatonin Receptor Agonist).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Ramelteon
- Donepezil
- Rifampin
- Fluvoxamine
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.