dorzolamide vs dorzolamide/timolol
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Side-by-side comparison of dorzolamide and dorzolamide/timolol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.2 High-Dose Salicylate Therapy Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy).
Trusopt
Cosopt
Dorzolamide eye drops help lower pressure in the eye. It is used for people with ocular hypertension or open-angle glaucoma.
Cosopt is an eye drop that lowers pressure inside the eye. It combines two medicines to treat glaucoma and high eye pressure.
This medicine treats high pressure inside your eye. It is for people who have ocular hypertension or open-angle glaucoma. Dorzolamide helps to lower the pressure and prevent damage to your optic nerve.
Cosopt is used to lower high pressure in your eyes. It treats open-angle glaucoma and ocular hypertension. These conditions can damage the optic nerve and cause vision loss. Cosopt is for people who haven't responded well to beta-blocker eye drops alone.
Dorzolamide is a type of medicine called a carbonic anhydrase inhibitor. It works by decreasing the amount of fluid your eye makes. This lowers the pressure inside your eye.
Cosopt has two medicines. Dorzolamide lowers eye pressure by reducing fluid production in the eye. Timolol lowers eye pressure by blocking certain receptors in the eye.
- • Burning, stinging, or discomfort in the eye right after using the drops
- • Bitter taste in your mouth
- • Superficial punctate keratitis (small spots on the surface of the eye)
- • Signs and symptoms of an allergic reaction in the eye
- • Bitter, sour, or unusual taste
- • Eye burning or stinging
- • Redness of the eye
- • Blurred vision
- • Superficial punctate keratitis (small spots on the cornea)
- Treatment Failure 1,369
- Fatigue 444
- Headache 356
- Pain 321
- Eye Pain 292
- Treatment not working 1,369
- Tiredness 444
- Headache 356
- Pain 321
- Eye pain 292
Dorzolamide contains a sulfonamide. Rarely, severe reactions to sulfonamides have happened, even death. If you have signs of a serious reaction or allergy, stop using this medicine right away.
Cosopt contains timolol, which can cause breathing problems like asthma. If you have asthma or severe lung disease, you should not use Cosopt. Cosopt can also cause heart problems, including heart failure. If you have heart problems, talk to your doctor before using Cosopt. Cosopt contains dorzolamide, a sulfonamide. Rarely, severe reactions to sulfonamides, including fatal reactions, have occurred. If you have a sulfonamide allergy, you should not use Cosopt.
It is not known if dorzolamide is safe to use during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if dorzolamide passes into breast milk.
It is not known if Cosopt will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Cosopt passes into breast milk. Talk to your doctor about the best way to feed your baby if you use Cosopt.
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How to Read This dorzolamide vs dorzolamide/timolol Comparison
dorzolamide is classified in the Carbonic Anhydrase Inhibitor (Ophthalmic) drug class, while dorzolamide/timolol sits within the CAI / Beta-Blocker Combination (Ophthalmic) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dorzolamide has 2,782 submissions while dorzolamide/timolol has 2,782. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking two drugs that both contain dorzolamide can cause the medicine to build up in your body and lead to chemical imbalances in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for dorzolamide or dorzolamide/timolol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.