Oxcarbazepine and Rifampin Interaction
Drug interaction information between Oxcarbazepine and Rifampin.
Oxcarbazepine and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxcarbazepine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the way your body breaks down oxcarbazepine, which can lower the amount of active medicine in your blood by nearly half.
FDA Label Information
7.2 Effect of Other Drugs on Oxcarbazepine Strong inducers of cytochrome P450 enzymes and/or inducers of UGT (e.g., rifampin, carbamazepine, phenytoin and phenobarbital) have been shown to decrease the plasma/serum levels of MHD, the active metabolite of oxcarbazepine (25% to 49%) [see Clinical Pharmacology ( 12.3 )].
Oxcarbazepine Also Interacts With
- Dolutegravir/Lamivudine moderate
- Tranylcypromine moderate
- Phenytoin minor
- Phenobarbital minor
- Bictegravir/Emtricitabine/Tenofovir minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Oxcarbazepine + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Oxcarbazepine's 18. In the minor band specifically: Oxcarbazepine has 16 (also Phenytoin, Phenobarbital, Bictegravir, Carbamazepine); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Oxcarbazepine and Rifampin?
Rifampin speeds up the way your body breaks down oxcarbazepine, which can lower the amount of active medicine in your blood by nearly half.
Rifampin carries more major-labeled pairs than Oxcarbazepine
SPL source-record counts only. This page's band is minor · classes on file: Oxcarbazepine (Anticonvulsant); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Oxcarbazepine's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 16 minor · 18 total
- Other minor peers for Oxcarbazepine
- Phenytoin
- Phenobarbital
- Bictegravir
- Carbamazepine
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.