Diltiazem · larger labeled portfolio than Amiodarone
SPL labels Diltiazem + Amiodarone as minor; Diltiazem 35 / Amiodarone 29 in that band.
Mechanism on file: These drugs both work to slow the heart's electrical signals and rhythm. Using them at the same time can cause a dangerously slow heart rate or heart block.
FDA SPL severity: Minor
Diltiazem + Amiodarone · SPL mechanism field
These drugs both work to slow the heart's electrical signals and rhythm. Using them at the same time can cause a dangerously slow heart rate or heart block.
Minor band excerpt · Diltiazem with Amiodarone
Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.
Diltiazem · 46 SPL pairs (broader portfolio than Amiodarone)
- Buspirone minor
- Carbamazepine minor
- Carvedilol minor
- Cilostazol minor
Amiodarone · 29 minor + 42 total pairs
- Atenolol minor
- Atorvastatin minor
- Carvedilol minor
- Cholestyramine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.