Diltiazem · more major-labeled pairs than Carvedilol
SPL labels Diltiazem + Carvedilol as minor; Diltiazem 35 / Carvedilol 12 in that band.
Mechanism on file: Both drugs slow down the heart's electrical signals and lower blood pressure. This can cause the heart to beat too slowly or change its rhythm.
FDA SPL severity: Minor
Diltiazem + Carvedilol · SPL mechanism field
Both drugs slow down the heart's electrical signals and lower blood pressure. This can cause the heart to beat too slowly or change its rhythm.
Minor band excerpt · Diltiazem with Carvedilol
( 7.6 ) Verapamil- or diltiazem-type calcium channel blockers may affect ECG and/or blood pressure. 7.7 Calcium Channel Blockers Conduction disturbance (rarely with hemodynamic compromise) has been observed when carvedilol tablet is coadministered with diltiazem. As with other β-blocker, if carvedilol tablet is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.
Diltiazem · 4 major-labeled pairs (vs Carvedilol's 0)
- Amiodarone minor
- Buspirone minor
- Carbamazepine minor
- Cilostazol minor
Carvedilol · 12 minor + 13 total pairs
- Amiodarone minor
- Cimetidine minor
- Cyclosporine minor
- Darunavir minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
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