Desmopressin and Chlorpromazine Interaction
Drug interaction information between Desmopressin and Chlorpromazine.
Desmopressin and Chlorpromazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Desmopressin and Chlorpromazine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. This increases the risk of developing low sodium levels in your bloodstream.
What To Do
Your doctor should monitor you closely if you take these drugs together. Watch for signs of low sodium like headaches, confusion, or nausea.
FDA Label Information
tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.
Desmopressin Also Interacts With
- Lamotrigine moderate
- Carbamazepine moderate
Chlorpromazine Also Interacts With
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Carbamazepine minor
- Clozapine minor
Frequently Asked Questions
Can I take Desmopressin and Chlorpromazine together?
This is a moderate interaction. Your doctor should monitor you closely if you take these drugs together. Watch for signs of low sodium like headaches, confusion, or nausea.
How serious is the interaction between Desmopressin and Chlorpromazine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Desmopressin and Chlorpromazine interact?
Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. This increases the risk of developing low sodium levels in your bloodstream.
Understanding the Desmopressin and Chlorpromazine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Desmopressin belongs to the Vasopressin Analog class and Chlorpromazine belongs to the Typical Antipsychotic (Phenothiazine) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Desmopressin has 3 total documented interactions on file in this dataset, and Chlorpromazine has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you closely if you take these drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Desmopressin or Chlorpromazine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.