Desmopressin and Chlorpromazine Interaction
Drug interaction information between Desmopressin and Chlorpromazine.
Desmopressin and Chlorpromazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Desmopressin and Chlorpromazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. This increases the risk of developing low sodium levels in your bloodstream.
FDA Label Information
tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.
Desmopressin Also Interacts With
- Lamotrigine moderate
- Carbamazepine moderate
Chlorpromazine Also Interacts With
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Carbamazepine minor
- Clozapine minor
Frequently Asked Questions
What SPL severity band is on file for Desmopressin + Chlorpromazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Chlorpromazine has 11 labeled pairs on file vs Desmopressin's 3. In the moderate band specifically: Desmopressin has 3 (also Lamotrigine, Carbamazepine); Chlorpromazine has 4 (also Tetrabenazine, Tranylcypromine, Zolpidem).
What mechanism field is on file for Desmopressin and Chlorpromazine?
Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. This increases the risk of developing low sodium levels in your bloodstream.
Chlorpromazine's labeled portfolio outnumbers Desmopressin
SPL source-record counts only. This page's band is moderate · classes on file: Desmopressin (Vasopressin Analog); Chlorpromazine (Typical Antipsychotic (Phenothiazine)).
0 major · 3 moderate · 0 minor · 3 total
- Other moderate peers for Desmopressin
- Lamotrigine
- Carbamazepine
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Chlorpromazine
- Tetrabenazine
- Tranylcypromine
- Zolpidem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.