Bazedoxifene · larger labeled portfolio than Conjugated Estrogens
SPL labels Bazedoxifene + Conjugated Estrogens as minor; Bazedoxifene 7 / Conjugated Estrogens 1 in that band.
Mechanism on file: Itraconazole slows down how your body processes this medication, which can cause the levels of the drug in your blood to rise.
FDA SPL severity: Minor
Bazedoxifene + Conjugated Estrogens · SPL mechanism field
Itraconazole slows down how your body processes this medication, which can cause the levels of the drug in your blood to rise.
Minor band excerpt · Bazedoxifene with Conjugated Estrogens
Concomitant administration of itraconazole, a strong CYP3A4 inhibitor, with DUAVEE, resulted in increases in bazedoxifene exposure (40%) and, to a lesser extent, conjugated estrogens exposure (9% for baseline-adjusted total estrone, 5% for total equilin), compared to DUAVEE alone [see Pharmacokinetics (12.3) ] .
Bazedoxifene · 7 SPL pairs (broader portfolio than Conjugated Estrogens)
- Atorvastatin minor
- Carbamazepine minor
- Itraconazole minor
- Phenobarbital minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.