bazedoxifene/conjugated estrogens vs conjugated estrogens
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of bazedoxifene/conjugated estrogens and conjugated estrogens. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Concomitant administration of itraconazole, a strong CYP3A4 inhibitor, with DUAVEE, resulted in increases in bazedoxifene exposure (40%) and, to a lesser extent, conjugated estrogens exposure (9% for baseline-adjusted total estrone, 5% for total equilin), compared to DUAVEE alone [see Pharmacokinetics (12.3) ] .
Premarin
Duavee is a combination medicine containing estrogen and a drug that blocks estrogen in some parts of the body. It is used to treat menopause symptoms and prevent bone loss after menopause in women with a uterus.
Premarin Intravenous is an injectable medicine that contains estrogen hormones. It is used to quickly raise estrogen levels for a short time.
Duavee is used to treat moderate to severe hot flashes caused by menopause. It can also help prevent bone loss (osteoporosis) after menopause. You should only use Duavee if you are at significant risk of osteoporosis and other non-estrogen medications should be carefully considered. Use Duavee for the shortest time that works for you, based on your goals and risks.
Premarin Intravenous treats unusual bleeding from the uterus when it's caused by hormone problems and not by other health issues. It is only for short-term use. It helps to quickly and temporarily increase your estrogen levels.
Duavee contains two medicines. Estrogen helps with menopause symptoms and bone loss. Bazedoxifene blocks estrogen's effects in the uterus, which lowers the risk of uterine cancer that can happen when taking estrogen alone.
Premarin Intravenous contains estrogen hormones. These hormones help to control the menstrual cycle. By providing estrogen, it can help stop abnormal uterine bleeding caused by a hormone imbalance.
- • Muscle spasms
- • Nausea
- • Diarrhea
- • Upset stomach
- • Upper abdominal pain
- • Nausea
- • Headache
- • Dizziness
- • Joint pain
- • Anxiety
No adverse event reports.
- Breast Cancer 9,623
- Breast Cancer Female 8,862
- Nausea 2,360
- Headache 2,291
- Pain 2,248
Duavee has serious warnings. It can increase the risk of uterine cancer, stroke, blood clots, and dementia. Women taking Duavee should not take additional estrogens. Estrogen should not be used to prevent heart disease or dementia. Talk to your doctor about the risks and benefits of Duavee.
Estrogen-alone therapy can increase the risk of uterine cancer, stroke, blood clots, and dementia. Estrogen with progestin can increase the risk of blood clots, stroke, heart attack, and dementia. Use the lowest dose for the shortest time needed.
Do not take Duavee if you are pregnant. It can harm your unborn baby. Duavee is not for women who can get pregnant.
You should not use Premarin Intravenous if you are pregnant or think you might be pregnant. Talk to your doctor if you are breastfeeding before using this medicine.
How to Read This bazedoxifene/conjugated estrogens vs conjugated estrogens Comparison
bazedoxifene/conjugated estrogens is classified in the SERM / Estrogen Combination drug class, while conjugated estrogens sits within the Conjugated Estrogen class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, bazedoxifene/conjugated estrogens has 0 submissions while conjugated estrogens has 25,384. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole slows down how your body processes this medication, which can cause the levels of the drug in your blood to rise.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for bazedoxifene/conjugated estrogens or conjugated estrogens.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.