Azilsartan and Aliskiren Interaction
Drug interaction information between Azilsartan and Aliskiren.
Azilsartan and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Azilsartan and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs block the same system that controls blood pressure, which can cause your blood pressure to drop too low and strain your kidneys. This can also lead to dangerously high potassium levels in your blood.
FDA Label Information
7.2 Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with Edarbyclor in patients with diabetes. Avoid use of aliskiren with Edarbyclor in patients with renal impairment (GFR <60 mL/min).
Azilsartan Also Interacts With
- Chlorthalidone moderate
- Lithium moderate
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Benazepril major
- Candesartan major
- Enalapril major
Frequently Asked Questions
What SPL severity band is on file for Azilsartan + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Azilsartan's 3. In the major band specifically: Azilsartan has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Benazepril, Candesartan).
What mechanism field is on file for Azilsartan and Aliskiren?
Both drugs block the same system that controls blood pressure, which can cause your blood pressure to drop too low and strain your kidneys. This can also lead to dangerously high potassium levels in your blood.
Aliskiren carries more major-labeled pairs than Azilsartan
SPL source-record counts only. This page's band is major · classes on file: Azilsartan (Angiotensin II Receptor Blocker (ARB)); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Azilsartan's 1.
1 major · 2 moderate · 0 minor · 3 total
Azilsartan has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Benazepril
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.