Azilsartan and Lithium Interaction
Drug interaction information between Azilsartan and Lithium.
Azilsartan and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Azilsartan and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Azilsartan can make it harder for the kidneys to remove lithium from the body. This causes lithium levels to build up, which can lead to dangerous side effects.
FDA Label Information
7 DRUG INTERACTIONS Renal clearance of lithium is reduced by diuretics, such as chlorthalidone increasing the risk of lithium toxicity ( 7 ) NSAIDS increase risk of renal dysfunction and interfere with antihypertensive effect ( 7 ) Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7 ) Lithium: Increases in serum lithium concentrations and lithium toxicity ( 7 ) 7.1 Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including...
Azilsartan Also Interacts With
- Aliskiren major
- Chlorthalidone moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Azilsartan + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Azilsartan's 3. In the moderate band specifically: Azilsartan has 2 (also Chlorthalidone); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Benazepril).
What mechanism field is on file for Azilsartan and Lithium?
Azilsartan can make it harder for the kidneys to remove lithium from the body. This causes lithium levels to build up, which can lead to dangerous side effects.
Lithium carries more major-labeled pairs than Azilsartan
SPL source-record counts only. This page's band is moderate · classes on file: Azilsartan (Angiotensin II Receptor Blocker (ARB)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Azilsartan's 1. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 0 minor · 3 total
- Other moderate peers for Azilsartan
- Chlorthalidone
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.