Azilsartan and Chlorthalidone Interaction
Drug interaction information between Azilsartan and Chlorthalidone.
Azilsartan and Chlorthalidone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Azilsartan and Chlorthalidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs work in different ways to lower blood pressure, which can increase the risk of very low blood pressure and kidney problems.
FDA Label Information
7 DRUG INTERACTIONS Renal clearance of lithium is reduced by diuretics, such as chlorthalidone increasing the risk of lithium toxicity ( 7 ) NSAIDS increase risk of renal dysfunction and interfere with antihypertensive effect ( 7 ) Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7 ) Lithium: Increases in serum lithium concentrations and lithium toxicity ( 7 ) 7.1 Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including...
Chlorthalidone Also Interacts With
- Norepinephrine minor
- Fosinopril minor
Frequently Asked Questions
What SPL severity band is on file for Azilsartan + Chlorthalidone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Azilsartan and Chlorthalidone tie at 3 labeled pairs each. moderate-band counts: Azilsartan 2 alongside Lithium; Chlorthalidone 1.
What mechanism field is on file for Azilsartan and Chlorthalidone?
These drugs work in different ways to lower blood pressure, which can increase the risk of very low blood pressure and kidney problems.
Azilsartan carries more major-labeled pairs than Chlorthalidone
SPL source-record counts only. This page's band is moderate · classes on file: Azilsartan (Angiotensin II Receptor Blocker (ARB)); Chlorthalidone (Thiazide-Like Diuretic).
Azilsartan has 1 major-labeled pair vs Chlorthalidone's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 2 minor · 3 total
Chlorthalidone has no other moderate-band peer in this dataset besides Azilsartan.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.