Ibandronate and Ranitidine Interaction
Drug interaction information between Ibandronate and Ranitidine.
Ibandronate and Ranitidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ibandronate and Ranitidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranitidine increases the amount of ibandronate that is absorbed into your body.
FDA Label Information
7.3 H2 Blockers In healthy volunteers, co-administration with ranitidine resulted in a 20% increased bioavailability of ibandronate, which was not considered to be clinically relevant (see CLINICAL PHARMACOLOGY [12.3] ) . 7.3 H2 Blockers In healthy volunteers, co-administration with ranitidine resulted in a 20% increased bioavailability of ibandronate, which was not considered to be clinically relevant (see CLINICAL PHARMACOLOGY [12.3] ) .
Ranitidine Also Interacts With
- Risperidone major
- Theophylline major
- Valproate major
- Midazolam moderate
- Clonazepam minor
Frequently Asked Questions
What SPL severity band is on file for Ibandronate + Ranitidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranitidine has 15 labeled pairs on file vs Ibandronate's 2. In the minor band specifically: Ibandronate has 1; Ranitidine has 11 (also Clonazepam, Darunavir, Diltiazem, Eprosartan).
What mechanism field is on file for Ibandronate and Ranitidine?
Ranitidine increases the amount of ibandronate that is absorbed into your body.
Ranitidine carries more major-labeled pairs than Ibandronate
SPL source-record counts only. This page's band is minor · classes on file: Ibandronate (Bisphosphonate); Ranitidine (H2 Receptor Antagonist).
Ranitidine has 3 major-labeled pairs vs Ibandronate's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 1 minor · 2 total
Ibandronate has no other minor-band peer in this dataset besides Ranitidine.
3 major · 1 moderate · 11 minor · 15 total
- Other minor peers for Ranitidine
- Clonazepam
- Darunavir
- Diltiazem
- Eprosartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.