What the FDA labels say about taking them together
Alendronate and aspirin
Alendronate's FDA label of March 12, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name alendronate.
Check it at the source: the alendronate FDA label on DailyMed (effective March 12, 2026, Organon LLC); the aspirin FDA label on DailyMed (effective September 9, 2025).
What does the alendronate label say about aspirin?
Alendronate label, drug interactionsDRUG INTERACTIONS Calcium supplements, antacids, or oral medications containing multivalent cations interfere with absorption of alendronate. ( 2.6 , 7.1 ) Use caution when co-prescribing aspirin/nonsteroidal anti-inflammatory drugs that may worsen gastrointestinal irritation.
Source: FDA drug label (Binosto, NDA202344), Radius Health, Inc., effective February 6, 2026 (SPL set 09765234-01bc-40f7-b9bb-c167056f3909), via openFDA
Source: FDA drug label (FOSAMAX), Organon LLC, effective March 12, 2026 (SPL set 14e931fd-2c5f-4d90-b7db-5980706f4a56), via openFDA; the full label on DailyMed
What does the aspirin label say about alendronate?
Aspirin's label (effective September 9, 2025) does not name alendronate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alendronate | Aspirin | |
|---|---|---|
| Labeled for | Osteoporosis | Pain, Cough and cold, Fever |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.256 per tablet 70 mg tablet | $0.0142 per tablet 81 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once