Alternatives to sertraline
5 same-class SPL records vs sertraline - uses, FAERS reaction fields, and OTC/Rx flags from public FDA sources.
Brand: Zoloft
How to read a high-report FAERS peer set
sertraline ranks in the upper FAERS-volume third of the corpus (#67 of 524); 5 same-class peers are listed for field comparison only. Labeled indication field for sertraline: Sertraline is used to treat major depressive disorder in adults.
Top FAERS reaction fields for sertraline total 47,498 reports across 10 reactions, set beside citalopram, escitalopram, fluoxetine. Counts are exposure-weighted submissions, not per-patient risk.
About sertraline
Sertraline is a medicine used to treat depression and other mental health conditions. It helps balance chemicals in your brain to improve your mood and reduce anxiety.
Used for: Sertraline is used to treat major depressive disorder in adults. This means it can help with ongoing sadness or loss of interest in things. It also treats obsessive-compulsive disorder (OCD), where you have unwanted thoughts or behaviors that you can't control. Sertraline can also treat panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder.
5 Selective Serotonin Reuptake Inhibitor (SSRI) peers (wide set)
citalopram
RxCelexa
Citalopram is used to treat major depressive disorder (MDD) in adults. Depression can cause feelings of sadness, loss of interest, and difficulty functioning in daily life. This medicine can help improve your mood and overall well-being.
escitalopram
RxLexapro
Escitalopram is used to treat major depressive disorder (MDD) in adults and children 12 years and older. It also treats generalized anxiety disorder (GAD) in adults. This medicine can help improve your mood and reduce feelings of worry.
fluoxetine
RxProzac, Sarafem
Fluoxetine can treat major depressive disorder in adults and children. It also treats obsessive-compulsive disorder (OCD) in adults and children. Fluoxetine can help with bulimia nervosa (an eating disorder) and panic disorder. Sometimes, it is used with another medicine called olanzapine to treat depression related to bipolar disorder.
fluvoxamine
RxLuvox
Fluvoxamine is used to treat obsessive compulsive disorder (OCD). OCD involves having constant, unwanted thoughts or behaviors that you feel the need to repeat. These thoughts or actions can cause you distress and interfere with your daily life.
paroxetine
RxPaxil
Paroxetine is used to treat several conditions in adults. These include major depressive disorder (MDD), obsessive compulsive disorder (OCD), panic disorder (PD), social anxiety disorder (SAD), generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD). It helps to improve mood and reduce anxiety and panic feelings.
sertraline vs citalopram & escitalopram · FAERS reaction fields
FAERS top-reaction field "Fatigue" shows the widest count spread between sertraline and citalopram, escitalopram, fluoxetine in this extract (3,305-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | sertraline | citalopram | escitalopram | fluoxetine |
|---|---|---|---|---|
| Nausea | 6,466 | 8,210 | 9,164 | 3,233 |
| Fatigue | 5,891 | 8,930 | 9,196 | 3,156 |
| Diarrhoea | 5,216 | 6,218 | 6,709 | 2,374 |
| Headache | 4,927 | 6,656 | 7,114 | 2,774 |
| Dizziness | 4,599 | 5,705 | 6,087 | 2,357 |
| Anxiety | 4,553 | 5,436 | 6,447 | 2,444 |
| Drug Interaction | 4,192 | 4,348 | 3,707 | 3,335 |
| Vomiting | 4,142 | 4,951 | 5,090 | 2,241 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
sertraline FAERS volume vs class peers
FAERS volume band
sertraline is FAERS corpus rank #67 of 524 (high volume tercile). Top-reaction field total: 47,498.
Frequently Asked Questions
Where does sertraline sit in FAERS report volume vs Selective Serotonin Reuptake Inhibitor (SSRI) peers? ▼
Registry note: FAERS counts are voluntary reports and do not establish causation or risk rates. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for sertraline: see also the generic vs brand label guide when reading Zoloft SPL strings.
Read our methodology - how this data is sourced, computed, and verified.