FDA pharmacologic class
Proton pump inhibitors (PPIs)
6 medicines are in FDA's class of proton pump inhibitors (proton pump inhibitors): omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), lansoprazole (Prevacid), rabeprazole (Aciphex) and dexlansoprazole (Dexilant); 3 combination products also contain one. 8 of the 9 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is omeprazole dr 20 mg capsule at $0.0295 per capsule (NADAC).
Which medicines are proton pump inhibitors?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Omeprazole | Prilosec | 118 labelers | $0.0295 per capsule 20 mg capsule | No | A presentation being discontinued | 7 |
| Esomeprazole | Nexium | 116 labelers | $0.145 per capsule 20 mg capsule | No | No current entry | 12 |
| Pantoprazole | Protonix | 66 labelers | $0.0358 per tablet 40 mg tablet | No | No current entry | 25 |
| Lansoprazole | Prevacid | 59 labelers | $0.106 per capsule 30 mg capsule | No | No current entry | 15 |
| Omeprazole and sodium bicarbonate | Zegerid, Konvomep | 20 labelers | $7.90 per packet 40-1,680 packet | No | No current entry | 5 |
| Rabeprazole | Aciphex | 20 labelers | $0.224 per tablet 20 mg tablet | No | No current entry | 1 |
| Dexlansoprazole | Dexilant | 9 labelers | $3.71 per capsule 60 mg capsule | No | No current entry | 0 |
| Esomeprazole and naproxen | none listed | 10 labelers | $1.96 per unit 500-20 mg | Yes | No current entry | 0 |
| Amoxicillin and omeprazole and rifabutin | Talicia | none listed | $4.88 per capsule 10-250-12.5 mg capsule | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price