Prescription medicine
Meloxicam and rizatriptan Brand names: Symbravo
Meloxicam and rizatriptan (Symbravo) is a prescription medicine with an FDA approval on record since 2025. No generic is listed; pharmacies paid $122.64 per Symbravo 20-10 mg tablet in the October 7, 2026 NADAC survey.
- No generic listed
- Boxed warning
Check it at the source: the meloxicam and rizatriptan FDA label on DailyMed (effective November 21, 2025, Axsome Therapeutics, Inc.); the NDA 215431 record on Drugs@FDA; every meloxicam and rizatriptan label on DailyMed.
Highlights of the record
FDA label of November 21, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS.
Cardiovascular Risk Non-steroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use [see Warnings & Precautions (5.1) ]. SYMBRAVO is contraindicated in the setting of coronary artery bypass graft (CABG) surgery [see Contraindications (4), Warnings & Precautions (5.1) ]. Gastrointestinal Risk NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events [see Warnings & Precautions (5.2) ]. WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS See full prescribing information for complete boxed warning. Non-steroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction, and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use (5.1). […]
Used for
From the label: indications and usageSYMBRAVO is indicated for the acute treatment of migraine with or without aura in adults.
Forms and strengths
- 20 mg / 10 mg
Tablet.
On the market
- Earliest approval on file
- January 30, 2025 Symbravo, Axsome; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
- Last listed patent
- March 10, 2045 Symbravo tablets; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- $122.64 per tablet Symbravo 20-10 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 28 through July 30, 2026
What is meloxicam and rizatriptan used for?
From the label: indications and usageSYMBRAVO is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use SYMBRAVO should only be used where a clear diagnosis of migraine has been established. If a patient has no response for the first migraine attack treated with SYMBRAVO, the diagnosis of migraine should be reconsidered before SYMBRAVO is administered to treat any subsequent attacks. SYMBRAVO is not indicated for the preventive treatment of migraine attacks. SYMBRAVO is not indicated for the treatment of cluster headache. […]
Conditions named in the indications of meloxicam and rizatriptan's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Nonsteroidal Anti-inflammatory Drug and Serotonin-1b and Serotonin-1d Receptor Agonist.
Source: FDA drug label (SYMBRAVO), Axsome Therapeutics, Inc., effective November 21, 2025 (SPL set dcf1ecd1-08a0-8e47-e053-2a95a90abdc7), via openFDA; the full label on DailyMed
What does the patient leaflet for meloxicam and rizatriptan say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about SYMBRAVO?SYMBRAVO contains 2 medicines: meloxicam (a nonsteroidal anti-inflammatory drug [NSAID]) and rizatriptan (a triptan). NSAIDs, including SYMBRAVO, can cause serious side effects, including: Increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment and may increase: with increasing doses of NSAIDs with longer use of NSAIDs Do not take SYMBRAVO right before or after a heart surgery called a “coronary artery bypass graft (CABG).” Avoid taking SYMBRAVO after a recent heart attack unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack. Stop taking SYMBRAVO and get emergency help right away if you have any of the following symptoms of a heart attack or stroke: discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw pain or discomfort in your arms, back, neck, jaw, or stomach shortness of breath with or without chest discomfort breaking out in a cold sweat nausea or vomiting feeling lightheaded weakness in one part or on side of your body slurred speech SYMBRAVO is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. […]
From the patient leaflet: What should I avoid while taking SYMBRAVO?SYMBRAVO may cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything that needs you to be alert.
From the patient leaflet: How should I store SYMBRAVO?Store SYMBRAVO at room temperature between 68°F to 77°F (20°C to 25°C). Safely throw away medicine that is out of date or no longer needed. Keep SYMBRAVO and all medicines out of the reach of children.
Source: FDA drug label (SYMBRAVO), Axsome Therapeutics, Inc., effective November 21, 2025 (SPL set dcf1ecd1-08a0-8e47-e053-2a95a90abdc7), via openFDA; the full label on DailyMed
Is there a generic for meloxicam and rizatriptan (Symbravo)?
No generic meloxicam and rizatriptan is approved (Drugs@FDA, October 8, 2026).
The Orange Book lists 96 patents for Symbravo tablets, the last expiring on March 10, 2045. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 2025 earliest approval on file
- 2045 last listed patent
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for meloxicam and rizatriptan (Symbravo)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $122.64 per Symbravo 20-10 mg tablet, about the same as a year earlier. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Symbravo 20-10 mg tablet (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Symbravo 20-10 mg tablet | Brand | $122.64 per tablet | $3,679.29 | no change |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the meloxicam and rizatriptan label say about other medicines?
The meloxicam and rizatriptan label names 13 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Amiodarone | drug interactions | Clinical Impact; In vitro studies indicate that CYP2C9 (cytochrome P450 metabolizing enzyme) plays an important role in the metabolic pathway of meloxicam with a minor contribution of the CYP3A4 isozyme. … |
| Aspirin | contraindications | … the excipients in SYMBRAVO ( 4 ) History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs ( 4 ) Moderate to severe renal insufficiency in patients who are at risk for renal failure due to volume depletion or who are on dialysis |
| Cyclosporine | drug interactions | Cyclosporine Clinical Impact Concomitant use of meloxicam and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention During concomitant use of SYMBRAVO and cyclosporine, monitor patients for signs of worsening renal function. |
| Diflunisal | drug interactions | Clinical Impact; Concomitant use of meloxicam with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [see ]. |
| Dihydroergotamine | contraindications | … ( 4 ) Recent (within 24 hours) use of an ergotamine-containing medication, ergot-type medication (such as dihydroergotamine or methysergide), another 5-HT 1 agonist (e.g., another triptan) ( 4 ) Concurrent administration or recent discontinuation (i.e., within the past 2 weeks) of a MAO-A inhibitor ( 4 ) Known … |
| Ergotamine | warnings and precautions | Overuse of acute migraine drugs (e.g., ergotamine, triptans, opioids, or a combination of drugs for 10 or more days per month) may lead to exacerbation of headache (medication overuse headache). |
| Fluconazole | drug interactions | Clinical Impact; In vitro studies indicate that CYP2C9 (cytochrome P450 metabolizing enzyme) plays an important role in the metabolic pathway of meloxicam with a minor contribution of the CYP3A4 isozyme. … |
| Furosemide | drug interactions | NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics. |
| Lithium | drug interactions | Monitor for increases in lithium plasma levels ( 7.1 ) Methotrexate: Monitor for increases methotrexate plasma levels. ( 7.1 ). |
| Methotrexate | drug interactions | Monitor for increases in lithium plasma levels ( 7.1 ) Methotrexate: Monitor for increases methotrexate plasma levels. ( 7.1 ). |
| Pemetrexed | drug interactions | Clinical Impact; Concomitant use of meloxicam and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information). |
| Propranolol | contraindications | … Peripheral vascular disease ( 4 ) Ischemic bowel disease ( 4 ) Uncontrolled hypertension ( 4 ) Concomitant use of propranolol ( 4 ) Recent (within 24 hours) use of an ergotamine-containing medication, ergot-type medication (such as dihydroergotamine or methysergide), another 5-HT 1 agonist (e.g., another triptan) ( 4 … |
| Warfarin | drug interactions | Clinical Impact; Meloxicam and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of meloxicam and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin release by platelets plays an important role in hemostasis. … |
Source: FDA drug label (SYMBRAVO), Axsome Therapeutics, Inc., effective November 21, 2025 (SPL set dcf1ecd1-08a0-8e47-e053-2a95a90abdc7), via openFDA; the full label on DailyMed
What do FAERS reports show for meloxicam and rizatriptan?
The FDA Adverse Event Reporting System holds 28 reports that list meloxicam and rizatriptan among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 0 are coded as a death and 2 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as meloxicam and rizatriptan?
13 other medicines are given the same way (oral) and in the same FDA class as meloxicam and rizatriptan or labeled mainly for the same use (migraine), the same class first. Migraine lists all 27 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Celecoxib | Migraine | 65 labelers | $0.0762 per capsule 200 mg capsule | No current entry |
| Diclofenac | Migraine | 67 labelers | $0.0619 per tablet 75 mg tablet | A presentation being discontinued |
| Sumatriptan | Migraine | 22 labelers | $0.302 per tablet 50 mg tablet | No current entry |
| Zolmitriptan | Migraine | 18 labelers | $1.02 per tablet 2.5 mg tablet | No current entry |
| Eletriptan | Migraine | 10 labelers | $1.75 per tablet 40 mg tablet | No current entry |
| Naratriptan | Migraine | 4 labelers | $1.08 per tablet 2.5 mg tablet | No current entry |
| Almotriptan | Migraine | 3 labelers | $16.86 per tablet 12.5 mg tablet | No current entry |
| Naproxen and sumatriptan | Migraine | 3 labelers | $10.46 per unit 85-500 mg | No current entry |
Every medicine labeled for the same conditions as meloxicam and rizatriptan
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to meloxicam and rizatriptan
- 13 medicines for the same use
- Other NSAIDs
- the pharmacologic class, with prices and generics
- Meloxicam and rizatriptan side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other