Prescription medicine
Calcium chloride, potassium chloride, sodium chloride and sodium lactate
Calcium chloride, potassium chloride, sodium chloride and sodium lactate is a prescription medicine with an FDA approval on record since 1971. FDA's NDC Directory lists it from 2 generic labelers, and pharmacies paid $0.0038 per mL (Lactated ringers injection) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the calcium chloride, potassium chloride, sodium chloride and sodium lactate FDA label on DailyMed (effective October 29, 2025, Baxter Healthcare Company); the NDA 16682 record on Drugs@FDA; every calcium chloride, potassium chloride, sodium chloride and sodium lactate label on DailyMed.
Highlights of the record
FDA label of October 29, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageLactated Ringer’s Injection is indicated for use as a source of water and electrolytes or as an alkalinizing agent in adults and pediatric patients.
Forms and strengths
- 0.6 g/100ml / 0.31 g/100ml / 0.03 g/100ml / 0.02 g/100ml
- 6 g/1000ml / 3.1 g/1000ml / 300 mg/1000ml / 200 mg/1000ml
- 600 mg/100ml / 310 mg/100ml / 30 mg/100ml / 20 mg/100ml
- 600 mg/100ml / 310 mg/100ml / 20 mg/100ml / 30 mg/100ml
Injection (solution); irrigant; solution.
On the market
- Earliest approval on file
- March 22, 1971 Lactated Ringer'S In Plastic Container, Baxter Hlthcare; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 1 first January 28, 2019; 1 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 8 of which 2 under generic applications, 6 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.0038 per mL Lactated ringers injection
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 5 since 2024 3 Class I among all firms' recalls; latest August 12, 2026
- FAERS reports
- 972 through July 30, 2026
What is calcium chloride, potassium chloride, sodium chloride and sodium lactate used for?
From the label: indications and usageLactated Ringer’s Injection is indicated for use as a source of water and electrolytes or as an alkalinizing agent in adults and pediatric patients. Lactated Ringer’s Injection is indicated for use as a source of water and electrolytes or as an alkalinizing agent in adults and pediatric patients.
FDA pharmacologic class: Blood Coagulation Factor, Osmotic Laxative, Phosphate Binder and Potassium Salt.
Source: FDA drug label (Lactated Ringers), Baxter Healthcare Company, effective October 29, 2025 (SPL set dad7735c-709b-40ea-ab7a-15577e24a966), via openFDA; the full label on DailyMed
Is there a generic for calcium chloride, potassium chloride, sodium chloride and sodium lactate?
The FDA approved the first generic calcium chloride, potassium chloride, sodium chloride and sodium lactate on January 28, 2019. 1 generic application is approved; 1 of it carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists calcium chloride, potassium chloride, sodium chloride and sodium lactate from 2 labelers under a generic (ANDA) application and from 6 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1971 earliest approval on file
- 2019 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for calcium chloride, potassium chloride, sodium chloride and sodium lactate?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.0038 per mL (Lactated ringers injection), up 32% from $0.0029 on October 8, 2025. The survey records the price, not the reason for a change; large moves often follow a new generic or a list-price change. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Lactated ringers injection (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Lactated ringers injection | Generic | $0.0038 per mL | n/a | +32% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has calcium chloride, potassium chloride, sodium chloride and sodium lactate been recalled?
The FDA's Enforcement Report lists 5 recalls naming calcium chloride, potassium chloride, sodium chloride and sodium lactate since 2024: 3 Class I (the most serious), 2 Class II, 0 Class III; 4 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| August 12, 2026 | Class I | B BRAUN MEDICAL INC | Presence of Particulate matter. |
| April 28, 2026 | Class I | B BRAUN MEDICAL INC | Presence of Particulate Matter. |
| August 18, 2025 | Class I | B BRAUN MEDICAL INC | Presence of Particulate Matter |
| August 4, 2025 | Class II | B BRAUN MEDICAL INC | Lack of Assurance of Sterility; potential for fluid leakage at one of the weld sites. |
| March 22, 2024 | Class II | B. Braun Medical Inc | Lack of assurance of sterility: bags have the potential to leak.. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the calcium chloride, potassium chloride, sodium chloride and sodium lactate label say about other medicines?
The calcium chloride, potassium chloride, sodium chloride and sodium lactate label names 13 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Amiloride | drug interactions | The risk of hyperkalemia is increased in patients treated with agents or products that can cause hyperkalemia or increase the risk of hyperkalemia, such as potassium-sparing diuretics (amiloride, spironolactone, triameterene), with ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants … |
| Arginine | drug interactions | These drugs include diuretics and those that cause SIADH (e.g., arginine vasopressin analogs, certain antiepileptic, psychotropic, or cytotoxic drugs). |
| Ceftriaxone | contraindications | CONTRAINDICATIONS Lactated Ringer’s Injection is contraindicated in: Neonates (28 days of age or younger) who are receiving concomitant treatment with ceftriaxone, even if separate infusion lines are used, due to the risk of fatal ceftriaxone-calcium salt precipitation in the neonate’s bloodstream [see Warnings and … |
| Corticotropin | drug interactions | Hypernatremia and Fluid Retention Administration of Lactated Ringer’s Injection to patients treated concomitantly with drugs associated with sodium and fluid retention (e.g., corticosteroids or corticotropin) may increase the risk of hypernatremia and volume overload. |
| Cyclosporine | drug interactions | … triameterene), with ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine. |
| Dextroamphetamine | drug interactions | Renal clearance of alkaline drugs, such as sympathomimetics (e.g., ephedrine, pseudoephedrine), dextroamphetamine (dexamphetamine) sulfate, and fenfluramine (phenfluramine) hydrochloride may be decreased. |
| Digoxin | drug interactions | Digoxin: consider reducing the volume or rate of Lactated Ringer’s Injection due to the increased risk of digoxin toxicity with calcium-containing solutions. |
| Ephedrine | drug interactions | Renal clearance of alkaline drugs, such as sympathomimetics (e.g., ephedrine, pseudoephedrine), dextroamphetamine (dexamphetamine) sulfate, and fenfluramine (phenfluramine) hydrochloride may be decreased. |
| Fenfluramine | drug interactions | Renal clearance of alkaline drugs, such as sympathomimetics (e.g., ephedrine, pseudoephedrine), dextroamphetamine (dexamphetamine) sulfate, and fenfluramine (phenfluramine) hydrochloride may be decreased. |
| Lithium | drug interactions | If concomitant use is unavoidable, monitor serum lithium concentrations more frequently. |
| Pseudoephedrine | drug interactions | Renal clearance of alkaline drugs, such as sympathomimetics (e.g., ephedrine, pseudoephedrine), dextroamphetamine (dexamphetamine) sulfate, and fenfluramine (phenfluramine) hydrochloride may be decreased. |
| Spironolactone | drug interactions | The risk of hyperkalemia is increased in patients treated with agents or products that can cause hyperkalemia or increase the risk of hyperkalemia, such as potassium-sparing diuretics (amiloride, spironolactone, triameterene), with ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants … |
| Tacrolimus | drug interactions | … spironolactone, triameterene), with ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine. |
Source: FDA drug label (Lactated Ringers), Baxter Healthcare Company, effective October 29, 2025 (SPL set dad7735c-709b-40ea-ab7a-15577e24a966), via openFDA; the full label on DailyMed
What do FAERS reports show for calcium chloride, potassium chloride, sodium chloride and sodium lactate?
The FDA Adverse Event Reporting System holds 972 reports that list calcium chloride, potassium chloride, sodium chloride and sodium lactate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 111 are coded as a death and 298 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other blood coagulation factors
- the pharmacologic class, with prices and generics
- Calcium chloride, potassium chloride, sodium chloride and sodium lactate side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other