What the FDA labels say about taking them together
Arginine and calcium chloride, potassium chloride, sodium chloride and sodium lactate
Calcium chloride, potassium chloride, sodium chloride and sodium lactate's FDA label of October 29, 2025 names arginine in its drug interactions section; the arginine label PlainMeds reads does not name calcium chloride, potassium chloride, sodium chloride and sodium lactate. The calcium chloride, potassium chloride, sodium chloride and sodium lactate label: “The risk of hospital-acquired hyponatremia is increased in younger pediatric patients, geriatric patients, patients treated with diuretics, and patients with cardiac or pulmonary failure or with the syndrome of …”
Check it at the source: the arginine FDA label on DailyMed (effective April 2, 2024, Pharmacia & Upjohn Company LLC); the calcium chloride, potassium chloride, sodium chloride and sodium lactate FDA label on DailyMed (effective October 29, 2025, Baxter Healthcare Company).
What does the arginine label say about calcium chloride, potassium chloride, sodium chloride and sodium lactate?
Arginine's label (effective April 2, 2024) does not name calcium chloride, potassium chloride, sodium chloride and sodium lactate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (R-Gene), Pharmacia & Upjohn Company LLC, effective April 2, 2024 (SPL set 6accf33f-9841-4327-8923-93c42020ef12), via openFDA; the full label on DailyMed
What does the calcium chloride, potassium chloride, sodium chloride and sodium lactate label say about arginine?
Calcium chloride, potassium chloride, sodium chloride and sodium lactate label, drug interactionsThese drugs include diuretics and those that cause SIADH (e.g., arginine vasopressin analogs, certain antiepileptic, psychotropic, or cytotoxic drugs).
Calcium chloride, potassium chloride, sodium chloride and sodium lactate label, warnings and precautionsThe risk of hospital-acquired hyponatremia is increased in younger pediatric patients, geriatric patients, patients treated with diuretics, and patients with cardiac or pulmonary failure or with the syndrome of inappropriate antidiuretic hormone (SIADH) (e.g., postoperative patients, patients concomitantly treated with arginine vasopressin analogs, or certain antiepileptic, psychotropic, or cytotoxic drugs) [see Drug Interactions (7.1), Use in Specific Populations (8.4) ].
Source: FDA drug label (Lactated Ringers), Baxter Healthcare Company, effective October 29, 2025 (SPL set dad7735c-709b-40ea-ab7a-15577e24a966), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Arginine | Calcium chloride, potassium chloride, sodium chloride and sodium lactate | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0038 per mL Lactated ringers injection |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once