MID-VOLUME · HOSP-HEAVY
valproate Side Effects
valproate (also sold as Depakote, Depakene) sits MID-VOLUME #240 of 524 by FAERS report count. Lead signal: HOSP-HEAVY - 42.8% mention hospitalization (8,459 reports). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 19,772
- FAERS reports
FDA Adverse Event Reporting System extract for valproate. Stamp set WATCHLIST · DEATH-HEAVY · HOSP-HEAVY. How figures are compiled.
valproate: 42.8% mention hospitalization (8,459 reports). Death stamp DEATH-HEAVY; volume band MID-VOLUME #240 of 524 by FAERS report count.
Mid-book FAERS page for valproate (Depakote) (19,772 reports). Signature HOSP-HEAVY. Dominant age band on file: 18-44. Educational reference only.
Counts from the openFDA FAERS extract (2001–2025). Stamps WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
DRUG INTERACTION leads 1,185 of 19,772 reports
Who reports · age peak 18-44 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 18-44 (4,890 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (1,782 reports, 9.0%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 237 |
| SEPSIS | 104 |
| PNEUMONIA | 101 |
| CARDIAC ARREST | 97 |
| PYREXIA | 88 |
| TOXICITY TO VARIOUS AGENTS | 87 |
| DRUG INTERACTION | 82 |
| FOETAL EXPOSURE DURING PREGNANCY | 82 |
| MALAISE | 73 |
| VOMITING | 71 |
| STATUS EPILEPTICUS | 67 |
| CONVULSION | 66 |
| DIARRHOEA | 66 |
| COMPLETED SUICIDE | 62 |
| OVERDOSE | 53 |
| NAUSEA | 51 |
| CARDIO-RESPIRATORY ARREST | 50 |
| SUDDEN DEATH | 50 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (8,459, 42.8% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| DRUG INTERACTION | 595 |
| PYREXIA | 542 |
| SOMNOLENCE | 489 |
| TOXICITY TO VARIOUS AGENTS | 394 |
| VOMITING | 345 |
| SUICIDE ATTEMPT | 308 |
| PNEUMONIA | 304 |
| EPILEPSY | 297 |
| SEIZURE | 278 |
| CONFUSIONAL STATE | 277 |
| OVERDOSE | 272 |
| DIARRHOEA | 266 |
| FALL | 258 |
| MALAISE | 258 |
| CONVULSION | 257 |
| WEIGHT INCREASED | 256 |
| THROMBOCYTOPENIA | 245 |
| HYPOTENSION | 241 |
How to read valproate FAERS figures (WATCHLIST · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 19,772 voluntary reports linked to valproate (Depakote, Depakene), 2001-2025. Death is listed on 1,782 (9.0%). Hospitalization appears on 8,459 (42.8%). Top co-reported indication: Product Used For Unknown Indication.
Mid-volume extract - treat DEATH-HEAVY · HOSP-HEAVY as signal-detection rates next to 42.8% mention hospitalization (8,459 reports).
Read with valproate
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 19,831 FAERS cases (Δ 59 heavier vs valproate); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 19,891 FAERS cases (Δ 119 heavier vs valproate); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 19,947 FAERS cases (Δ 175 heavier vs valproate); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 20,197 FAERS cases (Δ 425 heavier vs valproate); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 53.1 pp vs valproate's DEATH-HEAVY): CASELOAD · HOSP-MID.
valproate stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload WATCHLIST and the label guide.