Drug side effects
rifaximin Side Effects
The reactions most often reported to the FDA for rifaximin (also sold as Xifaxan), with demographics, serious outcomes, and reporting trends.
Data updated 2026-05-15
- 19,891
- FAERS reports
Data from the FDA Adverse Event Reporting System (FAERS), 2004 to 2025. A FAERS report records a temporal association, not proof of cause. See our methodology for how figures are compiled and de-duplicated.
The most commonly reported side effects of rifaximin come from 19,891 reports to the FDA, broken down here by frequency, patient demographics, and serious outcomes.
This page analyzes 19,891 reports to the FDA Adverse Event Reporting System (FAERS) for rifaximin (Xifaxan): the reactions reported most often, who reported them, serious outcomes such as hospitalization, and year-over-year trends. A FAERS report does not prove the drug caused the effect, and report volume tracks how widely a drug is used, not how likely an effect is for any one person. Educational information, not medical advice.
Total Reports
19,891
Reports Mentioning Death
5,855
29.4% of reports — not proof the medicine caused the death
Hospitalizations
7,784
39.1% of reports
Top Indication
Product Used For Unknown Indication
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 5,855 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| DEATH | 3,977 |
| HEPATIC CIRRHOSIS | 378 |
| HEPATIC FAILURE | 329 |
| RENAL FAILURE | 251 |
| HOSPITALISATION | 208 |
| LIVER DISORDER | 176 |
| THERAPY INTERRUPTED | 170 |
| HEPATIC ENCEPHALOPATHY | 161 |
| HOSPICE CARE | 160 |
| PNEUMONIA | 144 |
| SEPSIS | 124 |
| FALL | 118 |
| AMMONIA INCREASED | 115 |
| HEPATIC CANCER | 112 |
| DIARRHOEA | 98 |
| INSURANCE ISSUE | 94 |
| MULTIPLE ORGAN DYSFUNCTION SYNDROME | 92 |
| CONDITION AGGRAVATED | 90 |
Reactions in Hospitalization Reports
Top reactions in 7,784 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| HOSPITALISATION | 1,697 |
| AMMONIA INCREASED | 696 |
| THERAPY INTERRUPTED | 628 |
| HEPATIC ENCEPHALOPATHY | 618 |
| CONFUSIONAL STATE | 473 |
| FALL | 445 |
| INABILITY TO AFFORD MEDICATION | 399 |
| DIARRHOEA | 398 |
| DEATH | 390 |
| INSURANCE ISSUE | 358 |
| PNEUMONIA | 343 |
| HEPATIC CIRRHOSIS | 335 |
| CONDITION AGGRAVATED | 316 |
| NAUSEA | 297 |
| DYSPNOEA | 284 |
| FATIGUE | 273 |
| LIVER DISORDER | 264 |
| ASCITES | 263 |
| HEPATIC FAILURE | 259 |
Nearby, Related Medications
What the FAERS Data Reveals About rifaximin Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 19,891 voluntary reports linked to rifaximin and its brand equivalents (Xifaxan), spanning 2004 through 2025. Of those, 5,855 (29.4%) listed death as an outcome and 7,784 (39.1%) involved hospitalization. The most common indication reported alongside adverse events was Product Used For Unknown Indication.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 52% were female and 48% male; age distribution skews toward 45-64, with 5,220 reports in that bracket. The single most reported reaction is death with 3,982 submissions, followed by hospitalisation and diarrhoea.
How to read these numbers
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice, speak with a licensed clinician about any side-effect concerns.
Drugs With a Similar FAERS Report Volume
Other medications with a total FDA adverse-event report count closest to rifaximin's 19,891.
Read our methodology - how this data is sourced, computed, and verified.