HIGH-VOLUME · FEMALE-LED
topiramate Side Effects
topiramate (also sold as Topamax) is HIGH-VOLUME in this FAERS book #85 of 524 by FAERS report count. Signature opener: FEMALE-LED - 78% of sex-coded reports are female (62,988 F / 17,680 M).
Data updated 2026-05-15
- 90,083
- FAERS reports
FAERS voluntary reports, 2001 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
topiramate reporting skew - 78% of sex-coded reports are female (62,988 F / 17,680 M). Volume band HIGH-VOLUME #85 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for topiramate (Topamax): 90,083 FAERS rows (2001-2025). Top named reactions: HEADACHE, NAUSEA, FATIGUE. Outcome stamps DEATH-HEAVY · HOSP-MID · FEMALE-LED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2001–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
HEADACHE leads 6,464 of 90,083 reports
FEMALE-LED reporters · age peak 18-44
Female-led reporters (78% of sex-coded rows)
Age peak 18-44 (23,728 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (6,485 reports, 7.2%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 1,318 |
| DEATH | 1,183 |
| TOXICITY TO VARIOUS AGENTS | 881 |
| WOUND | 704 |
| RASH | 703 |
| PAIN | 690 |
| GASTROOESOPHAGEAL REFLUX DISEASE | 685 |
| SYNOVITIS | 685 |
| FOLLICULITIS | 661 |
| CONDITION AGGRAVATED | 660 |
| SYSTEMIC LUPUS ERYTHEMATOSUS | 659 |
| TYPE 2 DIABETES MELLITUS | 658 |
| WEIGHT INCREASED | 653 |
| MATERNAL EXPOSURE DURING PREGNANCY | 647 |
| PEMPHIGUS | 643 |
| PERICARDITIS | 639 |
Reactions in Hospitalization Reports
Hospitalization mid-share (22,919, 25.4%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| HEADACHE | 1,846 |
| PAIN | 1,808 |
| NAUSEA | 1,704 |
| VOMITING | 1,663 |
| FATIGUE | 1,615 |
| PNEUMONIA | 1,430 |
| DEPRESSION | 1,391 |
| FALL | 1,359 |
| DYSPNOEA | 1,355 |
| DIARRHOEA | 1,295 |
| SEIZURE | 1,292 |
| DIZZINESS | 1,249 |
| MIGRAINE | 1,249 |
| CONDITION AGGRAVATED | 1,209 |
| CONFUSIONAL STATE | 1,155 |
| WEIGHT INCREASED | 1,137 |
| ASTHENIA | 1,117 |
| RASH | 1,076 |
How to read topiramate FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-MID)
FAERS holds 90,083 voluntary reports linked to topiramate (Topamax), 2001-2025. Death is listed on 6,485 (7.2%). Hospitalization appears on 22,919 (25.4%). Top co-reported indication: Product Used For Unknown Indication.
CASELOAD books overweight common drugs and loud reporting cultures; FEMALE-LED is the page opener, not a per-patient risk.
Read with topiramate
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 90,121 FAERS cases (Δ 38 heavier vs topiramate); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 90,652 FAERS cases (Δ 569 heavier vs topiramate); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 89,398 FAERS cases (Δ 685 lighter vs topiramate); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 91,655 FAERS cases (Δ 1,572 heavier vs topiramate); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 54.9 pp vs topiramate's DEATH-HEAVY): CASELOAD · HOSP-MID.
topiramate stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.