MID-VOLUME · FEMALE-LED
nitrofurantoin Side Effects
nitrofurantoin (also sold as Macrobid, Macrodantin) sits MID-VOLUME #266 of 524 by FAERS report count. Lead signal: FEMALE-LED - 84% of sex-coded reports are female (12,211 F / 2,274 M). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 15,757
- FAERS reports
FDA Adverse Event Reporting System extract for nitrofurantoin. Stamp set WATCHLIST · DEATH-HEAVY · HOSP-HEAVY. How figures are compiled.
nitrofurantoin reporting skew - 84% of sex-coded reports are female (12,211 F / 2,274 M). Volume band MID-VOLUME #266 of 524 by FAERS report count; caseload WATCHLIST.
Mid-book FAERS page for nitrofurantoin (Macrobid) (15,757 reports). Signature FEMALE-LED. Dominant age band on file: 45-64. Educational reference only.
Counts from the openFDA FAERS extract (2004–2025). Stamps WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
URINARY TRACT INFECTION leads 1,301 of 15,757 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (84% of sex-coded rows)
Age peak 45-64 (3,766 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (1,000 reports, 6.3%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 283 |
| URINARY TRACT INFECTION | 84 |
| DYSPNOEA | 77 |
| COMPLETED SUICIDE | 72 |
| ACUTE KIDNEY INJURY | 67 |
| PNEUMONIA | 65 |
| CHRONIC KIDNEY DISEASE | 58 |
| PAIN | 52 |
| RENAL FAILURE | 51 |
| SEPSIS | 45 |
| PYREXIA | 42 |
| FATIGUE | 40 |
| NAUSEA | 40 |
| DECREASED APPETITE | 38 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 37 |
| RESPIRATORY FAILURE | 37 |
| HEPATIC FAILURE | 36 |
| CONFUSIONAL STATE | 35 |
| ASTHENIA | 34 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (5,435, 34.5% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| URINARY TRACT INFECTION | 677 |
| DYSPNOEA | 483 |
| NAUSEA | 436 |
| PAIN | 403 |
| FATIGUE | 385 |
| PYREXIA | 382 |
| VOMITING | 364 |
| DIARRHOEA | 334 |
| PNEUMONIA | 312 |
| MALAISE | 308 |
| FALL | 306 |
| HEADACHE | 293 |
| ASTHENIA | 282 |
| ABDOMINAL PAIN | 264 |
| DIZZINESS | 259 |
| ACUTE KIDNEY INJURY | 246 |
| WEIGHT DECREASED | 242 |
| BACK PAIN | 237 |
| COUGH | 231 |
How to read nitrofurantoin FAERS figures (WATCHLIST · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 15,757 voluntary reports linked to nitrofurantoin (Macrobid, Macrodantin), 2004-2025. Death is listed on 1,000 (6.3%). Hospitalization appears on 5,435 (34.5%). Top co-reported indication: Product Used For Unknown Indication.
Mid-volume extract - treat DEATH-HEAVY · HOSP-HEAVY as signal-detection rates next to 84% of sex-coded reports are female (12,211 F / 2,274 M).
Read with nitrofurantoin
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 15,755 FAERS cases (Δ 2 lighter vs nitrofurantoin); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(total_reports) peer at 15,783 FAERS cases (Δ 26 heavier vs nitrofurantoin); DEATH-MARKED · HOSP-LIGHT · FEMALE-LED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(total_reports) peer at 15,846 FAERS cases (Δ 89 heavier vs nitrofurantoin); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(total_reports) peer at 15,616 FAERS cases (Δ 141 lighter vs nitrofurantoin); DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 55.8 pp vs nitrofurantoin's DEATH-HEAVY): CASELOAD · HOSP-MID.
nitrofurantoin stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload WATCHLIST and the label guide.