MID-VOLUME · SEX-BALANCED
esketamine Side Effects
esketamine (also sold as Spravato) sits MID-VOLUME #264 of 524 by FAERS report count. Lead signal: SEX-BALANCED - 66% of sex-coded reports are female (8,844 F / 4,563 M). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 15,846
- FAERS reports
FDA Adverse Event Reporting System extract for esketamine. Stamp set WATCHLIST · DEATH-MARKED · HOSP-MID. How figures are compiled.
esketamine reporting skew - 66% of sex-coded reports are female (8,844 F / 4,563 M). Volume band MID-VOLUME #264 of 524 by FAERS report count; caseload WATCHLIST.
Mid-book FAERS page for esketamine (Spravato) (15,846 reports). Signature SEX-BALANCED. Dominant age band on file: 18-44. Educational reference only.
Counts from the openFDA FAERS extract (2015–2025). Stamps WATCHLIST · DEATH-MARKED · HOSP-MID · SEX-BALANCED.
DISSOCIATION leads 3,351 of 15,846 reports
Who reports · age peak 18-44 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 18-44 (4,243 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death appears on 641 reports (4.0% - MARKED). Reactions below co-occur in those rows only.
| Reaction | Reports |
|---|---|
| DEATH | 291 |
| COMPLETED SUICIDE | 229 |
| ROAD TRAFFIC ACCIDENT | 15 |
| OVERDOSE | 13 |
| SUICIDAL IDEATION | 13 |
| DEPRESSION | 12 |
| SEDATION | 11 |
| DISSOCIATION | 10 |
| MYOCARDIAL INFARCTION | 10 |
| SUICIDE ATTEMPT | 10 |
| ANXIETY | 9 |
| COVID-19 | 8 |
| CARDIAC ARREST | 7 |
| HOSPITALISATION | 7 |
| FALL | 6 |
| INTENTIONAL OVERDOSE | 5 |
| NEOPLASM MALIGNANT | 5 |
| PULMONARY EMBOLISM | 5 |
Reactions in Hospitalization Reports
Hospitalization mid-share (2,714, 17.1%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| HOSPITALISATION | 696 |
| SUICIDAL IDEATION | 329 |
| DISSOCIATION | 313 |
| SEDATION | 207 |
| DEPRESSION | 198 |
| SUICIDE ATTEMPT | 172 |
| HYPERTENSION | 117 |
| ANXIETY | 89 |
| NAUSEA | 71 |
| BLOOD PRESSURE INCREASED | 67 |
| VOMITING | 66 |
| DIZZINESS | 63 |
| SURGERY | 63 |
| FALL | 53 |
| SEIZURE | 52 |
| PANIC ATTACK | 49 |
| MENTAL DISORDER | 44 |
How to read esketamine FAERS figures (WATCHLIST · DEATH-MARKED · HOSP-MID)
FAERS holds 15,846 voluntary reports linked to esketamine (Spravato), 2015-2025. Death is listed on 641 (4.0%). Hospitalization appears on 2,714 (17.1%). Top co-reported indication: Depression.
Mid-volume extract - treat DEATH-MARKED · HOSP-MID as signal-detection rates next to 66% of sex-coded reports are female (8,844 F / 4,563 M).
Read with esketamine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-MARKED · HOSP-MID stamps.
ABS(total_reports) peer at 15,783 FAERS cases (Δ 63 lighter vs esketamine); DEATH-MARKED · HOSP-LIGHT · FEMALE-LED vs this page's WATCHLIST · DEATH-MARKED · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 15,757 FAERS cases (Δ 89 lighter vs esketamine); DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED vs this page's WATCHLIST · DEATH-MARKED · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 15,755 FAERS cases (Δ 91 lighter vs esketamine); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's WATCHLIST · DEATH-MARKED · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 16,005 FAERS cases (Δ 159 heavier vs esketamine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-MARKED · HOSP-MID · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 58.1 pp vs esketamine's DEATH-MARKED): CASELOAD · HOSP-MID.
esketamine stamps WATCHLIST · SEX-BALANCED; class peers and methodology beat restating the same FAERS caveats on every effects URL.