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What the label lists and what reports show

Natamycin side effects

Natamycin's FDA label lists its adverse reactions in its own words. FAERS holds 398 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is somnolence (57 reports).

  • No generic listed

Check it at the source: the natamycin FDA label on DailyMed (effective October 30, 2025, Harrow Eye, LLC); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions

The following events have been identified during post-marketing use of NATACYN ™ (natamycin ophthalmic suspension) 5% in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The events, which have been chosen for inclusion due to their seriousness, frequency of reporting, possible causal connection to NATACYN™ (natamycin ophthalmic suspension) 5%, or a combination of these factors include: allergic reaction, change in vision, chest pain, corneal opacity, dyspnea, eye discomfort, eye edema, eye hyperemia, eye irritation, eye pain, foreign body sensation, parethesia, and tearing.

Source: FDA drug label, Harrow Eye, LLC, effective October 30, 2025 (SPL set 20ede08c-0d39-dc65-e063-6394a90aa3e0), via openFDA; the full label on DailyMed

What do FAERS reports show?

398 reports list natamycin among the medicines taken, each a report of something that happened, not proof the medicine caused it; 88 are coded as a death and 150 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 22 reactions below, none is named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

The 25 most reported reactions

  • Drug Ineffective (a use or a product term, not a reaction)110
  • Condition Aggravated (a use or a product term, not a reaction)92
  • Off Label Use (a use or a product term, not a reaction)74
  • Somnolence57
  • Abdominal Distension54
  • Vomiting54
  • Abdominal Pain53
  • Appendicitis52
  • Appendicolith52
  • Ascites52
  • Nausea52
  • Dry Mouth51
  • Ventricular Fibrillation51
  • Constipation50
  • General Physical Health Deterioration50
  • Cardiogenic Shock48
  • Diabetes Mellitus48
  • Hyponatraemia48
  • Multiple Organ Dysfunction Syndrome48
  • Sepsis48
  • Blood Phosphorus Increased47
  • Myasthenia Gravis47
  • Stress47
  • Swelling47
  • Thrombosis47

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Natamycin: the full record
label, generics, price, shortages, recalls
Side effects hub
the most reported medicines and reactions