Gepirone Brand names: Exxua

What is gepirone used for?

From the label: indications and usage

EXXUA is indicated for the treatment of major depressive disorder (MDD) in adults. EXXUA is indicated for the treatment of major depressive disorder (MDD) in adults ( 1 ).

Conditions named in the indications of gepirone's FDA labels, with every medicine labeled for each:

• Depression

What does the patient leaflet for gepirone say first?

The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.

From the patient leaflet: What is the most important information I should know about EXXUA?

EXXUA may cause serious side effects, including: Increased risk of suicidal thoughts and actions. EXXUA and other antidepressant medicines may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. EXXUA is not for use in children. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. How can I watch for and try to prevent suicidal thoughts and actions in myself or family member? Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts, or feelings or if you develop suicidal thoughts or actions. This is very important when an antidepressant medicine is started or when the dose is changed. Call your healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings or if you develop suicidal thoughts or actions. Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you have concerns about symptoms. Call a healthcare provider or get emergency medical help right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying new or worse depression feeling very agitated or restless trouble sleeping (insomnia) acting aggressive, being angry, or violent an extreme increase in activity and talking (mania) attempts to commit suicide new or worse anxiety panic attacks new or worse irritability acting on dangerous impulses other unusual changes in behavior or mood

From the patient leaflet: How should I store EXXUA?

Store EXXUA at room temperature between 68°F to 77°F (20°C to 25°C) Protect from high humidity and moisture. Keep EXXUA and all medicines out of the reach of children.

Is there a generic for gepirone (Exxua)?

No generic gepirone is approved (Drugs@FDA, October 8, 2026).

The Orange Book lists 1 patent for Exxua tablets, the last expiring on September 2, 2030. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.

What do pharmacies pay for gepirone (Exxua)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $57.47 per tablet (Exxua ER 18.2 mg tablet (titratn)). NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

What does the gepirone label say about other medicines?

The gepirone label names 2 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Check gepirone against other medicines

What do FAERS reports show for gepirone?

The FDA Adverse Event Reporting System holds 2 reports that list gepirone among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 0 are coded as a death and 0 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

The most reported reactions

• Anger1
• Anxiety (named in the label)1
• Drug Ineffective (a use or a product term, not a reaction)1
• Headache (named in the label)1
• Illness (named in the label)1
• Insomnia (named in the label)1
• Nervousness1
• Overdose (a use or a product term, not a reaction)1

What else is labeled for the same conditions as gepirone?

30 other medicines are given the same way (oral) and in the same FDA class as gepirone or labeled mainly for the same use (depression), the same class first. Depression lists all 37 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

Every medicine labeled for the same conditions as gepirone

What next?

Alternatives to gepirone

30 medicines for the same use

Gepirone side effects

the label's list beside FAERS reports

Check an interaction

what two or more labels say about each other