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ferrous sulfate Side Effects

Also known as: Feosol, Fer-In-Sol

Analysis of 47,788 adverse event reports submitted to the FDA from 1995 to 2025.

Total Reports

47,788

Death-Related

5,418

11.3% of reports

Hospitalizations

20,748

43.4% of reports

Top Indication

Product Used For Unknown Indication

Most Reported Adverse Reactions

FATIGUE
3,325
DIARRHOEA
3,100
NAUSEA
2,746
DYSPNOEA
2,724
DEATH
2,345
OFF LABEL USE
2,306
ACUTE KIDNEY INJURY
2,070
ANAEMIA
1,967
PNEUMONIA
1,944
HEADACHE
1,922
ASTHENIA
1,919
PAIN
1,891
DIZZINESS
1,857
VOMITING
1,780
FALL
1,771
DRUG INEFFECTIVE
1,507
CHRONIC KIDNEY DISEASE
1,458
WEIGHT DECREASED
1,390
MALAISE
1,337
RENAL FAILURE
1,314

Who Reports Side Effects

Gender Distribution

Female 27,653 (62%)
Male 16,612 (37%)
Unknown 36

Age Distribution

0-17 1,588 (5%)
18-44 5,119 (15%)
45-64 9,211 (28%)
65-74 7,760 (23%)
75+ 9,412 (28%)

Reporting Trend by Year

1995 2025

Reactions in Death Reports

Top reactions reported in 5,418 reports where death was an outcome. These are voluntarily reported and do not establish causation.

Reaction Reports
DEATH 2,335
DYSPNOEA 397
ACUTE KIDNEY INJURY 386
PNEUMONIA 361
RENAL FAILURE 304
ANAEMIA 265
GASTROINTESTINAL HAEMORRHAGE 242
FATIGUE 237
SEPSIS 237
CHRONIC KIDNEY DISEASE 232
ASTHENIA 223
FALL 218
HYPOTENSION 210
NAUSEA 206
RESPIRATORY FAILURE 206
OFF LABEL USE 204
CARDIAC ARREST 203
DIARRHOEA 201
VOMITING 195
CARDIAC FAILURE CONGESTIVE 169

Reactions in Hospitalization Reports

Top reactions in 20,748 reports where hospitalization was an outcome.

Reaction Reports
DYSPNOEA 1,732
PNEUMONIA 1,597
DIARRHOEA 1,396
ACUTE KIDNEY INJURY 1,375
ANAEMIA 1,343
FATIGUE 1,210
FALL 1,203
NAUSEA 1,180
ASTHENIA 1,098
VOMITING 1,028
GASTROINTESTINAL HAEMORRHAGE 968
PYREXIA 920
HYPOTENSION 856
OFF LABEL USE 844
PAIN 832
URINARY TRACT INFECTION 829
DIZZINESS 828
HEADACHE 746
HAEMOGLOBIN DECREASED 715
WEIGHT DECREASED 712

Nearby — Related Medications

Compare ferrous sulfate vs ascorbic acid →

What the FAERS Data Reveals About ferrous sulfate Side Effects

The FDA Adverse Event Reporting System (FAERS) contains 47,788 voluntary reports linked to ferrous sulfate and its brand equivalents (Feosol, Fer-In-Sol), spanning 1995 through 2025. Of those, 5,418 (11.3%) listed death as an outcome and 20,748 (43.4%) involved hospitalization. The most common indication reported alongside adverse events was Product Used For Unknown Indication.

Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 62% were female and 37% male; age distribution skews toward 75+, with 9,412 reports in that bracket. The single most reported reaction is fatigue with 3,325 submissions, followed by diarrhoea and nausea.

FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice — speak with a licensed clinician about any side-effect concerns.