Over-the-counter medicine
Dimethicone and loperamide Brand names: Imodium
Dimethicone and loperamide (Imodium) is an over-the-counter medicine. FDA's NDC Directory lists it from 33 generic labelers, and pharmacies paid $0.286 per unit (Gs anti-diarrheal-antigas cplt) in the October 7, 2026 NADAC survey.
- Generic listed
- Over the counter
Check it at the source: the dimethicone and loperamide FDA label on DailyMed (effective August 25, 2026); every dimethicone and loperamide label on DailyMed.
Highlights of the record
FDA label of August 25, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usagerelieves symptoms of diarrhea plus bloating, pressure and cramps, commonly referred to as gas
Forms and strengths
- 2 mg / 125 mg
- 125 mg / 2 mg
Tablet.
On the market
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 34 of which 33 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.286 per unit Gs anti-diarrheal-antigas cplt
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 31,902 through July 30, 2026
What is dimethicone and loperamide used for?
From the label: indications and usagerelieves symptoms of diarrhea plus bloating, pressure and cramps, commonly referred to as gas
Conditions named in the indications of dimethicone and loperamide's FDA labels, with every medicine labeled for each:
From other dimethicone and loperamide labelsDiarrhea: Uses relieves symptoms of diarrhea plus bloating, pressure and cramps, commonly referred to as gas
FDA pharmacologic class: Opioid Agonist.
Source: FDA drug label (IMODIUM Multi-Symptom Relief), Kenvue Brands LLC, effective August 25, 2026 (SPL set ecb91e47-2b0c-47c8-9256-4623d8bc825e), via openFDA; the full label on DailyMed
Is there a generic for dimethicone and loperamide (Imodium)?
No generic dimethicone and loperamide is approved (Drugs@FDA, October 8, 2026).
FDA's NDC Directory lists dimethicone and loperamide from 33 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for dimethicone and loperamide (Imodium)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.286 per unit (Gs anti-diarrheal-antigas cplt), about the same as a year earlier. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Gs anti-diarrheal-antigas cplt (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Ft anti-diarrheal-antigas cplt | Generic | $0.286 per unit | n/a | -0.9% |
| Gnp anti-diarrheal-gas cplt | Generic | $0.286 per unit | n/a | -0.9% |
| Gs anti-diarrheal-antigas cplt | Generic | $0.286 per unit | n/a | -0.9% |
| Loperamide-simeth 2-125 mg tablet | Generic | $0.286 per tablet | $8.57 | -0.9% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for dimethicone and loperamide?
The FDA Adverse Event Reporting System holds 31,902 reports that list dimethicone and loperamide among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 2,527 are coded as a death and 11,229 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as dimethicone and loperamide?
9 other medicines are given the same way (oral) and in the same FDA class as dimethicone and loperamide or labeled mainly for the same use (diarrhea), the same class first. Diarrhea lists all 16 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Bismuth subsalicylate | Diarrhea | none listed | $0.0817 per tablet 262 mg tablet chewable | No current entry |
| Ciprofloxacin | Diarrhea | 46 labelers | $0.123 per tablet 500 mg tablet | No current entry |
| Atropine and diphenoxylate | Diarrhea | 19 labelers | $0.139 per tablet 2.5-0.025 mg tablet | No current entry |
| Nitazoxanide | Diarrhea | 4 labelers | $82.20 per tablet 500 mg tablet | No current entry |
| Rifaximin | Diarrhea | none listed | n/a | No current entry |
| Atropine and difenoxin | Diarrhea | none listed | $6.91 per tablet 1-0.025 mg tablet | No current entry |
| Octreotide | Diarrhea | none listed | n/a | No current entry |
| Telotristat | Diarrhea | none listed | n/a | No current entry |
Every medicine labeled for the same conditions as dimethicone and loperamide
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to dimethicone and loperamide
- 9 medicines for the same use
- Other opioids
- the pharmacologic class, with prices and generics
- Dimethicone and loperamide side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other